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Polycomb repression of gene expression is critical for development, with a pivotal role for trimethylation of lysine 27 of histone H3 (H3K27me3) deposited by Polycomb Repressive Complex 2 (PRC2). While the function and regulation of PRC2 have been extensively studied, the mechanism(s) by which it is...
ORGANISM(S): Mus musculus (Mouse) 
2018-05-07 | PXD005821 | Pride
To further explore the function of Mtf2, the homolog of Drosophila Polycomb group gene PCL, we have employed the mouse whole genome microarray expression profiling as a discovery platform to identify genes mediated by Mtf2. Oligos of 2 different RNAi target sites on gene Mtf2 were cloned into RNAi V...
ORGANISM(S): Mus musculus 
Chromatin-bound Mtf2 Restricts Extraembryonic Competence in Naïve Pluripotency
Chromatin-bound Mtf2 Restricts Extraembryonic Competence in Naïve Pluripotency [Cut & Tag]
EPOP and MTF2 Activate PRC2 Activity through DNA-sequence specificity
Chromatin-bound Mtf2 Restricts Extraembryonic Competence in Naïve Pluripotency [scRNA-Seq]
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