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ProteomicsMechanistic insights into RNA surveillance by the canonical poly(A) polymerase Pla1 of the MTREC complex
The S. pombe orthologue of the human PAXT complex, Mtl1-Red1 Core (MTREC), is an eleven-subunit complex which targets cryptic unstable transcripts (CUTs) to the nuclear RNA exosome for degradation. It encompasses the canonical poly(A) polymerase Pla1, responsible for polyadenylation of nascent RNA t...
ORGANISM(S): Fungi Schizosaccharomyces pombe SPK1820 
2022-12-01 | PXD035413 | Pride
Mtrec complex  s. pombe  paxt complex  rna surveilance 
ProteomicsThe fission yeast MTREC complex targets CUTs and unspliced mRNAs to the nuclear exosome
Cryptic unstable transcripts (CUTs) are rapidly degraded by the nuclear exosome. However, the mechanism by which they are recognized and targeted to the exosome is not fully understood. Here, we report that the MTREC complex, which has recently been shown to promote degradation of meiotic mRNAs and ...
ORGANISM(S): Schizosaccharomyces pombe 
2015-04-22 | PXD001908 | Pride
Cuts Rna surveillance Mtrec Tramp Rna decay Splicing Ncrna 
TranscriptomicsThe fission yeast MTREC complex targets CUTs and unspliced mRNAs to the nuclear exosome [RIP-ChIP]
Cryptic unstable transcripts (CUTs) are rapidly degraded by the nuclear exosome, however, the way they are recognized and targeted to the exosome is not fully understood. The recently identified Schizosaccharomyces pombe MTREC complex has been shown to promote degradation of meiotic mRNAs and regula...
ORGANISM(S): Schizosaccharomyces pombe 
2015-05-22 | E-GEOD-64980 | biostudies-arrayexpress
TranscriptomicsThe fission yeast MTREC complex targets CUTs and unspliced mRNAs to the nuclear exosome [expression array]
Cryptic unstable transcripts (CUTs) are rapidly degraded by the nuclear exosome, however, the way they are recognized and targeted to the exosome is not fully understood. The recently identified Schizosaccharomyces pombe MTREC complex has been shown to promote degradation of meiotic mRNAs and regula...
ORGANISM(S): Schizosaccharomyces pombe 
2015-05-22 | E-GEOD-64979 | biostudies-arrayexpress
TranscriptomicsThe fission yeast MTREC complex targets CUTs and unspliced mRNAs to the nuclear exosome [RNA-Seq]
Cryptic unstable transcripts (CUTs) are rapidly degraded by the nuclear exosome, however, the way they are recognized and targeted to the exosome is not fully understood. The recently identified Schizosaccharomyces pombe MTREC complex has been shown to promote degradation of meiotic mRNAs and regula...
ORGANISM(S): Schizosaccharomyces pombe 
2015-05-22 | E-GEOD-64991 | biostudies-arrayexpress
TranscriptomicsThe fission yeast MTREC complex targets CUTs and unspliced mRNAs to the nuclear exosome [expression array]
Cryptic unstable transcripts (CUTs) are rapidly degraded by the nuclear exosome, however, the way they are recognized and targeted to the exosome is not fully understood. The recently identified Schizosaccharomyces pombe MTREC complex has been shown to promote degradation of meiotic mRNAs and regula...
ORGANISM(S): Schizosaccharomyces pombe 
2015-05-22 | GSE64979 | GEO
TranscriptomicsThe fission yeast MTREC complex targets CUTs and unspliced mRNAs to the nuclear exosome [RIP-ChIP]
Cryptic unstable transcripts (CUTs) are rapidly degraded by the nuclear exosome, however, the way they are recognized and targeted to the exosome is not fully understood. The recently identified Schizosaccharomyces pombe MTREC complex has been shown to promote degradation of meiotic mRNAs and regula...
ORGANISM(S): Schizosaccharomyces pombe 
2015-05-22 | GSE64980 | GEO
TranscriptomicsThe fission yeast MTREC complex targets CUTs and unspliced mRNAs to the nuclear exosome [RNA-Seq]
Cryptic unstable transcripts (CUTs) are rapidly degraded by the nuclear exosome, however, the way they are recognized and targeted to the exosome is not fully understood. The recently identified Schizosaccharomyces pombe MTREC complex has been shown to promote degradation of meiotic mRNAs and regula...
ORGANISM(S): Schizosaccharomyces pombe 
2015-05-22 | GSE64991 | GEO
UnknownThe fission yeast MTREC complex targets CUTs and unspliced pre-mRNAs to the nuclear exosome.
Not available
S-EPMC4455066 | biostudies-literature
UnknownMechanistic insights into RNA surveillance by the canonical poly(A) polymerase Pla1 of the MTREC complex.
Not available
S-EPMC9922296 | biostudies-literature
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