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TranscriptomicsRNA-seq reveals that Air1 and Air2 control TRAMP substrate specificity for nuclear RNA surveillance
The Saccharomyces cerevisiae TRAMP4 and TRAMP5 complexes, which consist of the poly(A) polymerase Trf4 or Trf5, respectively, the zinc knuckle proteins Air1 or Air2, and the RNA helicase Mtr4, play a critical role in nuclear RNA surveillance. Although it is known to enhance the nuclease activity of ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-11-14 | E-GEOD-42231 | biostudies-arrayexpress
ProteomicsSubstrate Specificity of the TRAMP Nuclear Surveillance Complexes
During nuclear surveillance in yeast, the RNA exosome functions together with the TRAMP complexes. These include the DEAH-box RNA helicase Mtr4 together with an RNA-binding protein (Air1 or Air2) and a poly(A) polymerase (Trf4 or Trf5). To better determine how RNA substrates are targeted, we analyze...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-07-02 | PXD017114 | Pride
Trf4 Trf5 Nuclear surveillance Tramp complexes Rna-binding proteins 
ProteomicsHDX-MS of the TRAMP Complex with tRNA
TRAMP is a eukaryotic protein complex with RNA helicase and polyadenylase activity that marks and delivers a variety of RNA substrates to the nuclear exosome for degradation. Prior work has characterized binding of Trf4 and Air2 to the helicase core of Mtr4 and the regulation of both enzymatic activ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-12-11 | PXD053773 | Pride
Hdx Trf4 Tramp Air2 Rna Hdx-ms Mtr4 
TranscriptomicsLow dose PDT - Murine Cells
Murine prostate carcinoma cell lines TRAMP-C1 and TRAMP-C2 were grown for 16 h at 37M-0C with photosensitizer 5-aminolaevulinic acid (5-ALA; 50 M-5g/ml). Then, the cells were sublethally irradiated with laser light (635 nm) at room temperature (using RPMI1640 without phenol red as medium). After ph...
ORGANISM(S): Mus musculus 
2011-06-25 | E-MEXP-3016 | biostudies-arrayexpress
GenomicsExpression data derived from adenocarcinoma or neuroendocrine prostate cancer of TRAMP and SPARC deficient TRAMP mice.
Expression data derived from adenocarcinoma or neuroendocrine prostate cancer of TRAMP and SPARC deficient TRAMP mice.
PRJNA1014781 | ENA
TranscriptomicsTranscription profiling of mouse transgenic prostate adenocarcinoma cell line TRAMP-C2
Gene expression profiling of TRAMP-C2, transgenic adenocarcinoma of mouse prostate, cell line. The experiment was done to see which genes were over- or underexpressed in the cell line. The results were combined with aCGH results of the same samples (experiment Gene copy number profiling of TRAMP-C2 ...
ORGANISM(S): Mus musculus 
2008-09-11 | E-MEXP-1610 | biostudies-arrayexpress
TranscriptomicsExpression data from the dorsal and lateral lobes of the prostates of TRAMP mice treated with OSU-CG5
Cells undergoing malignant transformation often shift their cellular metabolism from primarily oxidative phosphorylation to aerobic glycolysis (the Warburg effect). Energy restriction-mimetic agents (ERMAs), such as 2-deoxyglucose and resveratrol, that target this shift in cellular metabolism have b...
ORGANISM(S): Mus musculus 
2013-01-06 | E-GEOD-32422 | biostudies-arrayexpress
GenomicsSubstrate Specificity of the TRAMP Nuclear Surveillance Complexes
Substrate Specificity of the TRAMP Nuclear Surveillance Complexes
PRJNA559170 | ENA
TranscriptomicsTranscription profiling of mouse transgenic adenocarcinoma of the prostate (TRAMP)
Gene expression profile of Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) reveals murine targets for preclinical development of human prostate cancer therapy; In this study, we have generated an open source TRAMP microarray dataset to identify differentially expressed genes from human prost...
ORGANISM(S): Mus musculus 
2009-01-14 | E-GEOD-10525 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of prostate tumors arisen in TRAMP mice in which mast cells are pharmacologically stabilized or genetically ablated.
Analysis of gene expression of prostate tumors arisen in TRAMP mice in which mast cells are pharmacologically stabilized or genetically ablated.The hypothesis tested in the present study was that mast cells inhibition or absence impacted prostate tumor development and histotype. Results demonstrate ...
ORGANISM(S): Mus musculus 
2011-06-15 | E-GEOD-29956 | biostudies-arrayexpress
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