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ProteomicsHydrogen-deuterium exchange mass spectrometry of wt Mtr4 with various RNA substrates
Mtr4 is a eukaryotic RNA helicase required for RNA decay by the nuclear exosome. Previous studies have shown how RNA enroute to the exosome threads through the highly conserved helicase core of Mtr4. Mtr4 also contains an arch domain, although details of potential interactions between the arch and R...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-03-07 | PXD031962 | Pride
Hdx Helicase Hdx-ms Mtr4 Bottom-up hdx 
ProteomicsHDX-MS of the TRAMP Complex with tRNA
TRAMP is a eukaryotic protein complex with RNA helicase and polyadenylase activity that marks and delivers a variety of RNA substrates to the nuclear exosome for degradation. Prior work has characterized binding of Trf4 and Air2 to the helicase core of Mtr4 and the regulation of both enzymatic activ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-12-11 | PXD053773 | Pride
Hdx Trf4 Tramp Air2 Rna Hdx-ms Mtr4 
GenomicsRip-seq of MTR4 in PLC/PRF5
Rip-seq of MTR4 in PLC/PRF5
PRJNA530682 | ENA
TranscriptomicsChIP-Chip
The regulation of protein-coding and noncoding RNAs is linked to nuclear processes including chromatin modifications and gene silencing. However, the mechanisms that distinguish RNAs and mediate their functions are poorly understood. We describe a nuclear RNA processing network in fission yeast with...
ORGANISM(S): Schizosaccharomyces pombe 
2013-11-21 | E-MTAB-1962 | biostudies-arrayexpress
GenomicsXrn1-sensitive lncRNAs accumulate upon inactivation of Dbp2 and Mtr4
Xrn1-sensitive lncRNAs accumulate upon inactivation of Dbp2 and Mtr4
PRJNA986459 | ENA
UnknownMtr4 RNA helicase structures and interactions.
Not available
S-EPMC8247069 | biostudies-literature
TranscriptomicsRip-seq of MTR4 in PLC/PRF5
Metabolic switch from oxidative phosphorylation to glycolysis is required for tumorigenesis by providing cancer cells with energy and substrates of biosynthesis, and also plays a key role in inducing immune suppressive tumor microenvironment that inhibits tumor immunotherapy. Therefore, to develop m...
ORGANISM(S): Homo sapiens 
2019-12-19 | GSE129261 | GEO
UnknownStructural basis for MTR4-ZCCHC8 interactions that stimulate the MTR4 helicase in the nuclear exosome-targeting complex.
Not available
S-EPMC6004480 | biostudies-literature
Transcriptomicstiling hen2 and mtr4-HEN2 is a cofactor of the nuclear exosome in Arabidopsis
til-ath-2011_3 - tiling hen2 and mtr4 - Identification and comparison of the RNA substrates that accumulate in hen2 and mtr4 mutants. Total RNA extracted from WT, hen2 and mtr4 mutants was used for oligo-dT primed cDNA preparation. Samples were hybridised to NimbleGen whole genome tiling arrays. 8 d...
ORGANISM(S): Arabidopsis thaliana 
2013-06-30 | E-GEOD-48178 | biostudies-arrayexpress
GenomicsThe nuclear exosome co-factor MTR4 shapes the transcriptome for meiotic initiation (LACE-Seq)
The nuclear exosome co-factor MTR4 shapes the transcriptome for meiotic initiation (LACE-Seq)
PRJNA1064128 | ENA
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