Sort   by:  
 Page size 
ProteomicsHuman mitochondria require mtRF1 for translation termination at non-canonical stop codons
Mitochondrial translation system highly diverged from its bacterial counterpart. This includes deviation from the universal genetic code, with AGA and AGG having no cognate tRNAs in human mitochondria. Their locations at the end of COX1 and ND6 open reading frames, respectively, suggests they functi...
ORGANISM(S): Homo sapiens (Human) 
2022-11-16 | PXD034342 | Pride
Mtrf1 Tmt Mitochondria Translation 
GenomicsMitoribosome profiling (MitoRiboSeq) data from HEK293T wild-type, MTRF1 KO, MTRF1A KO, MTRF1/MTRF1A dKO and N2a wild-type, MTRF1 KO, MTRF1A KO, MTRF1/MTRF1A dKO cells
Mitoribosome profiling (MitoRiboSeq) data from HEK293T wild-type, MTRF1 KO, MTRF1A KO, MTRF1/MTRF1A dKO and N2a wild-type, MTRF1 KO, MTRF1A KO, MTRF1/MTRF1A dKO cells
PRJEB128548 | ENA
GenomicsMitoribosome profiling (MitoRiboSeq) data from HEK293 wild-type, mtRF1a KO, mtRF1/mtRF1a dKO and N2a wild-type, mtRF1 KO, mtRF1a KO, mtRF1/mtRF1a dKO cells
Mitoribosome profiling (MitoRiboSeq) data from HEK293 wild-type, mtRF1a KO, mtRF1/mtRF1a dKO and N2a wild-type, mtRF1 KO, mtRF1a KO, mtRF1/mtRF1a dKO cells
PRJEB91731 | ENA
GenomicsmtRF1 recognises non-canonical stop codons in human mitochondria
mtRF1 recognises non-canonical stop codons in human mitochondria
PRJNA896508 | ENA
TranscriptomicsMitoribosome profiling (MitoRiboSeq) data from HEK WT and mtRF1 knockout cell lines
Mitochondrial translation was investigated by mitochondrial ribosome profiling (mitoRiboSeq) in three HEK293 cell lines: HEK293 wildtype, mtRF1 knockout 1, and mtRF1 knockout 2
ORGANISM(S): Homo sapiens 
2022-12-01 | E-MTAB-11687 | biostudies-arrayexpress
TranscriptomicsMitoribosome profiling (MitoRiboSeq) data from HEK293T wild-type, MTRF1 KO, MTRF1A KO, MTRF1/MTRF1A dKO; and N2a wild-type, MTRF1 KO, MTRF1A KO, MTRF1/MTRF1A dKO cells
Mitoribosome profiling data to investigate mitochondrial translation termination and stop codon readthrough following loss of the mitochondrial release factors mtRF1 and mtRF1a. Mouse N2a (Mus musculus) and human HEK293T (Homo sapiens) cells were analysed across four genotypes: wild-type (WT), MTRF1...
ORGANISM(S): Homo sapiens 
2026-10-19 | E-MTAB-17801 | biostudies-arrayexpress
GenomicsMolecular basis of non-canonical stop codon recognition by mtRF1 in human mitochondria
Molecular basis of non-canonical stop codon recognition by mtRF1 in human mitochondria
PRJNA895374 | ENA
OthermtRF1 recognises non-canonical stop codons in human mitochondria
The genetic code that specifies the identity of amino acids incorporated into proteins during protein synthesis is almost universally conserved. Mitochondrial translation deviates from the standard genetic code which includes the reassignment of two arginine codons into stop codons {Jukes, 1993 #438...
ORGANISM(S): Homo sapiens 
2023-03-21 | GSE216979 | GEO
UnknownHuman mitochondria require mtRF1 for translation termination at non-canonical stop codons.
Not available
S-EPMC9810596 | biostudies-literature
UnknownHuman mtRF1 terminates COX1 translation and its ablation induces mitochondrial ribosome-associated quality control.
Not available
S-EPMC9613700 | biostudies-literature
Sort   by:  
 Page size