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Mucins and glycoproteins with mucin-like regions contain densely O-glycosylated domains often found in tandem repeat (TR) sequences. These O-glycodomains have traditionally been difficult to characterize because of resistance to proteolytic digestion, and knowledge of positions of O-glycans is parti...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD029885 | Pride
Transcriptomic profiles of Candida albicans grown in the presence or absence of mucins
Transcriptomic profiles of Streptococcus mutans UA159 grown in the presence or absence of mucins or mucin glycans
The mucus lining wet body surfaces forms the interphase and barrier for the microbiota and resident microbiomes. Large mucin proteins densely decorated with O-glycans make up the mucus lining to entrap, feed and shape the microbiota, and repress biofilm formation and virulence. How mucins exert thes...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD066932 | Pride
We use high-throughput sequencing to profile the response of the opportunistic fungal pathogen Candida albicans to mucins from the mucosal niche. We find that C. albicans undergoes a genome-wide phenotypic shift in response to mucins suppressing virulence-associated pathways.
ORGANISM(S): Candida albicans 
2022-02-26 | GSE197249 | GEO
We use high-throughput sequencing to profile the response of oral commensal pathogen Streptococcus mutans to mucins protein polymers (human MUC5B mucins) and soluble mucin glycans (human MUC5B glycans and porcine MUC5AC glycans). We find that mucins and their glycans alter the regulation of dozens o...
ORGANISM(S): Streptococcus mutans 
2021-01-01 | GSE163258 | GEO
Targeted protein degradation is an emerging strategy for the elimination of classically undruggable proteins. Here, to expand the landscape of targetable substrates, we designed degraders that achieve substrate selectivity via recognition of a discrete peptide- and glycan- motif and achieve cell-typ...
ORGANISM(S): Homo sapiens (Human) 
2023-07-21 | PXD042243 | Pride
Transcriptomic profiles of Pseudomonas aeruginosa PA14 grown in the presence or absence of mucins or mucin-glycans
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