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TranscriptomicsImatinib targeting of KIT-mutant oncoprotein in melanoma
Metastatic melanoma is an aggressive treatment-refractory malignancy. Recently, c-Kit mutations were discovered in certain mucosal melanomas. A clinical trial was initiated with the c-Kit inhibitor imatinib mesylate. The first treated patient experienced dramatic clinical improvement within days, f...
ORGANISM(S): Homo sapiens 
2008-12-23 | E-GEOD-8164 | biostudies-arrayexpress
GenomicMucosal Melanoma Targeted Sequencing Study (UCSF)

Mucosal melanoma is a deadly disease that carries the worst prognosis amongst subtypes of melanoma. Like all melanomas, mucosal melanomas are frequently driven by activating mutations in the MAPK and/or PI3K pathways; however, unlike melanomas that arise on sun-exposed skin, mucosal melanomas har...

phs001594 | dbGaP
GenomicsWhole genome sequencing and whole exome sequencing of mucosal melanoma
We conducted whole genome sequencing of 5 mucosal melanomas and their matched DNA from blood. We conducted whole exome sequencing of a further 5 mucosal melanomas and their matched DNA from blood.
EGAS00001000474 | EGA
GenomicsConjunctival and mucosal melanoma
Conjunctival and mucosal melanoma
PRJNA602317 | ENA
TranscriptomicsCharacterization of the melanoma miRNAome by deep sequencing
MicroRNAs are 18-23 nucleotide non-coding RNAs that regulate gene expression in a sequence specific manner. Little is known about the repertoire and function of miRNAs in melanoma or the melanocytic lineage. We therefore undertook a comprehensive analysis of the miRNAome in a diverse range of pigmen...
ORGANISM(S): Homo sapiens 
2010-03-22 | E-GEOD-18381 | biostudies-arrayexpress
ProteomicsIntegration of functional precision oncology testing defines immunotherapies strategies for mucosal melanomas.
Mucosal melanomas (MM) arise from mucosal melanocytes at different anatomical sites. MM are rare and highly aggressive, and their outcome is very poor.  Only dismal clinical benefits have been obtained for the disseminated disease, with very limited promising results using approved immune checkpoint...
ORGANISM(S): Homo sapiens (Human) 
2026-03-16 | PXD059186 | Pride
Proteomics Ifngamma Mucosal melanoma 
GenomicsWhole genome sequencing of primary and metastatic Melanoma cases in an Australian cohort.
Melanoma is the fourth most common cancer in Australia and the leading cause of cancer death in young adults. The Australian Melanoma Genome Project (AMGP) is analysing whole genomes from melanomas. We include the results of whole genome sequencing (WGS) for a number of datasets that include cutaneo...
EGAS00001001552 | EGA
GenomicsWhole transcriptome analysis of mucosal melanoma
Whole transcriptome analysis of mucosal melanoma
PRJNA847678 | ENA
GenomicsWhole transcriptome analysis of mucosal melanoma
Whole transcriptome analysis of mucosal melanoma
PRJNA847677 | ENA
ProteomicsNovel cellular systems unveil mucosal melanoma initiating cells and a role for PI3K/Akt/mTOR pathway in mucosal melanoma fitness
Mucosal Melanomas (MM) are highly aggressive neoplasms arising from mucosal melanocytes. Current treatments offer a limited survival benefit for patients with advanced MM; moreover, the lack of pre-clinical cellular systems has significantly limited the understanding of their immunobiology. By morph...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD037551 | Pride
Mucosal melanomas Proteomics Cancer cell lines Pre-clinical models Cell line-derived xenografts Melanosomes 
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