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TranscriptomicsExpression profiling of fibroblasts treated with melanosomes
mRNA profiling was performed on primary fibroblasts treated with melanosomes and untreated fibroblasts as control. The aim of this study was to explore whether melanoma-derived mature melanosomes functionally affect primary fibroblasts. A functional gene set enrichment analysis based on the resultin...
ORGANISM(S): Homo sapiens 
2016-08-09 | E-GEOD-72229 | biostudies-arrayexpress
ProteomicsSecond-Hand Melanoma Melanosomes Regulate Diversity Among Tumor-Associated Macrophages
Extracellular vesicles (EVs) are a key form of cell-to-cell communication. Here we reveal a new mode of communication involving the large EVs, melanosomes. Unlike small EVsexosomes, which are dissolved in the receiver cell, melanosomes stay intact within them, gain a unique protein signature, and ca...
ORGANISM(S): Homo sapiens (Human) 
2023-12-31 | PXD046421 | Pride
Melanosomes Macrophages Small ev 
GenomicsLet-7 mediates the pro-lymphangiogenic effect of melanosomes
Let-7 mediates the pro-lymphangiogenic effect of melanosomes
PRJNA903968 | ENA
GenomicsSecond-Hand Melanoma Melanosomes Regulate Diversity Among Tumor-Associated Macrophages
Second-Hand Melanoma Melanosomes Regulate Diversity Among Tumor-Associated Macrophages
PRJNA1032944 | ENA
TranscriptomicsExpression profiling of fibroblasts treated with melanosomes
mRNA profiling was performed on primary fibroblasts treated with melanosomes and untreated fibroblasts as control. The aim of this study was to explore whether melanoma-derived mature melanosomes functionally affect primary fibroblasts. A functional gene set enrichment analysis based on the resultin...
ORGANISM(S): Homo sapiens 
2016-08-09 | GSE72229 | GEO
ProteomicsImmunopeptidomic analyses - HLA Export by Melanoma Cells Decoys Cytotoxic T Cells to Promote Immune Evasion
While melanoma cells often express a high burden of mutated proteins, the infiltration of reactive T cells rarely results in tumor-eradicating immunity. We discovered that large extracellular vesicles, known as melanosomes, secreted by melanoma cells are decorated with MHC molecules that stimulate C...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-04-19 | PXD069094 | Pride
Melanoma Melanosomes Immunopeptidome 
TranscriptomicsAnalysis of melanosomal, exosomal and cellular miRNAs of melanoma cells
miRNA microarray profiling was performed for exosomes and secreted melanosomes of MNT-1 cells as well as WM3682 and WM3314 cells and melanosomes isolated from cell homogenates. The aim of this study is to compare the miRNA content of exosomes and secreted melanosomes and to assess differences in the...
ORGANISM(S): Homo sapiens 
2016-08-09 | E-GEOD-79411 | biostudies-arrayexpress
TranscriptomicsLet-7 mediates the pro-lymphangiogenic effect of melanosomes
Melanoma-derived melanosomes traffic mature let-7i to lymphatic endothelial cells, which mediate pro-lymphangiogenic phenotypic changes by the induction of type I interferon signaling. Further, transcriptome analysis upon treatments with melanosomes or let-7i reveal the enhancement of IFI6 expressio...
ORGANISM(S): Homo sapiens 
2023-02-23 | GSE218501 | GEO
TranscriptomicsSecond-Hand Melanoma Melanosomes Regulate Diversity Among Tumor-Associated Macrophages
Extracellular vesicles (EVs) are a key form of cell-to-cell communication. Here we reveal a new mode of communication involving the large EVs, melanosomes. Unlike small EVs, which are dissolved in the receiver cell, melanosomes stay intact within them, gain a unique protein signature, and can then b...
ORGANISM(S): Homo sapiens 
2023-12-31 | GSE246446 | GEO
TranscriptomicsAnalysis of melanosomal miRNAs
miRNA microarray profiling was performed for MNT-1 cells, pre-mature and mature melanosomes extracted from MNT-1 cells. In order to reveal the miRNAs that are most abundant in mature melanosomes, the most highly expressed miRNAs from mature melanosomes were compared with expression levels in pre-mat...
ORGANISM(S): Homo sapiens 
2016-08-09 | E-GEOD-72337 | biostudies-arrayexpress
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