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MetabolomicsImproving global feature detectabilities through scan range splitting for untargeted metabolomics by high-performance liquid chromatography-Orbitrap mass spectrometry
Untargeted metabolomics aims at obtaining quantitative information on the highest possible number of low-molecular biomolecules present in a biological sample. Rather small changes in mass spectrometric spectrum acquisition parameters may have a significant influence on the detectabilities of metabo...
2016-06-09 | MTBLS233 | MetaboLights
ProteomicsA prion-like protein from a red-type pyrenoid forms heterotypic Rubisco condensates via sticker tetrads
The slow kinetics and poor substrate specificity of the key photosynthetic CO2-fixing enzyme Rubisco have prompted the repeated evolution of Rubisco containing compartments known as pyrenoids in diverse algal lineages and carboxysomes in prokaryotes. Inside these compartments actively transported bi...
ORGANISM(S): Phaeodactylum tricornutum (strain CCAP 1055/1) 
2023-06-13 | PXD027027 | Pride
Pyrenoid Phaeodactylum tricornutum Rubisco 
TranscriptomicsGene expression analysis of lung cancer samples and healthy controls
Non-small cell lung cancer (NSCLC, n=22) and normal adjacent control biopsies (n=18) from patients with lung cancer were obtained for Affymetrix GeneChip analysis. NSCLC samples were grouped into squamous cell carcinoma (SCC, n=11) and adenocarcinoma (AC, n=11) samples.
ORGANISM(S): Homo sapiens 
2017-07-01 | E-MTAB-5231 | biostudies-arrayexpress
ProteomicsPeripheral priming induces plastic transcriptomic and proteomic responses in circulating neutrophils required for pathogen containment
Neutrophils rapidly respond to inflammation and infection, but to which degree their functional trajectories after mobilization from the bone marrow can be shaped within the circulation remains vague. Phenotypic changes of circulating neutrophils caused by systemic inflammation are thought to result...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD048335 | Pride
Neutrophils - transcriptomic plasticity - sepsis - infectious disease - multiomics 
UnknownStochastic pausing at latent HIV-1 promoters generates transcriptional bursting.
Not available
S-EPMC8302722 | biostudies-literature
UnknownEvaluation of individual and ensemble probabilistic forecasts of COVID-19 mortality in the United States.
Not available
S-EPMC9169655 | biostudies-literature
TranscriptomicsThe activation of IL-1-induced enhancers depends on TAK1 kinase activity and NF-kappaB p65 II
The inflammatory gene response requires activation of the protein kinase TAK1, but it is currently unknown how TAK1-derived signals coordinate transcriptional programs in the genome. We determined the genome-wide binding of the TAK1-controlled NF-M-NM-:B subunit p65 in relation to active enhancers a...
ORGANISM(S): Homo sapiens 
2014-12-17 | E-GEOD-64237 | biostudies-arrayexpress
TranscriptomicsCyclin-dependent kinase 6 is a chromatin-bound cofactor for nuclear factor kappaB-dependent gene expression [Agilent]
Given the intimate link between inflammation and dysregulated cell proliferation in cancer we investigated cytokine-triggered gene expression in different cell cycle stages. High density microarray analysis revealed that G1 release primes and cooperates with the cytokine-driven gene response. This e...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-52465 | biostudies-arrayexpress
TranscriptomicsThe activation of IL-1-induced enhancers depends on TAK1 kinase activity and NF-kappaB p65 I
The inflammatory gene response requires activation of the protein kinase TAK1, but it is currently unknown how TAK1-derived signals coordinate transcriptional programs in the genome. We determined the genome-wide binding of the TAK1-controlled NF-M-NM-:B subunit p65 in relation to active enhancers a...
ORGANISM(S): Homo sapiens 
2014-12-17 | E-GEOD-64201 | biostudies-arrayexpress
UnknownCOVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records.
Not available
S-EPMC9179175 | biostudies-literature
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