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ProteomicsThe adaptive molecular landscape to reprogrammed telomeric sequences
Telomeric sequences vary across the tree of life and intimately co-evolve with telomere-binding protein complexes. However, the molecular mechanisms allowing organisms to adapt to new telomeric sequences are difficult to gauge from extant species. Here, we reprogrammed multiple yeast lines to human-...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-02-19 | PXD064562 | Pride
Telomeres Evolution Genome instability Yeast Dna damage response 
ProteomicsAn INS-1 𝛽-cell proteome highlights the role of fatty acid biosynthesis in glucose-stimulated insulin secretion
Pancreatic beta cells secrete insulin as a response to rising glucose levels in the blood, a process that is known as glucose-stimulated insulin secretion (GSIS). Although GSIS has been extensively studied, not all associated mechanisms are fully understood at the molecular level. In this study, we ...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-07-07 | PXD053750 | Pride
Beta cells Insulin secretion Glucose stimulation Quantitative proteomics 
ProteomicsUnlocking the Zn-enriching Potential of Industrial Yeast Strains – an experimental journey from metal analysis to proteomics
Nutritional supplements like trace element enriched yeasts become increasingly popular to overcome the worldwide problem of zinc (Zn) deficiency. Unlike Selenium-enriched yeast, Zn-enriched yeasts (ZnY) have not yet been authorised in the European Union, as their evaluation is still ongoing demandin...
ORGANISM(S): Saccharomyces pastorianus Saccharomyces cerevisiae (Baker's yeast) 
2025-12-28 | PXD065844 | Pride
Zinc speciation Xanes Zinc supplement Zinc-enriched yeast 
ProteomicsThe proteome landscape of genome-wide genetic perturbations
Despite the massive research efforts of the post-genomics era, a significant fraction of genes remain without functional annotation. Proteomics holds the promise to close significant gaps, but has only recently reached the scalability and precision of genome-scale studies. Here we combine large-scal...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2022-08-15 | MSV000090136 | MassIVE
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