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ProteomicsIdentification of vitamin K-dependent proteins in mouse liver by LC-MS/MS
Vitamin K (VK), a fat-soluble vitamin, functions as a co-factor during the gamma-carboxylation reaction that converts glutamic acid residues to gamma-carboxyglutamic acid residues in proteins transiting through the endoplasmic reticulum. Two enzymes are involved which together form the VK cycle: gam...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD032920 | Pride
Gamma-carboxylation Mouse Liver Vitamin k Lc-ms/ms 
UnknownGlycine as a D-amino acid surrogate in the K(+)-selectivity filter.
Not available
S-EPMC535378 | biostudies-literature
UnknownVitamin K-dependent carboxylation regulates Ca<sup>2+</sup> flux and adaptation to metabolic stress in β cells.
Not available
S-EPMC10305719 | biostudies-literature
ProteomicsIdentification of gamma-carboxyglutamic acid residues in mouse ERGP by LC-MS/MS.
Vitamin K (VK) is a micronutrient required for the gamma-carboxylation of secreted proteins. Clinical studies have recently implicated VK in the pathophysiology of diabetes. Our data indicate that rodent beta-cells lacking gamma-carboxylation fail to adapt their insulin secretion in response to gluc...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD032955 | Pride
Junctate Gamma-carboxylation Mouse Vitamin k Lc-ms/ms 
ProteomicsHistone monoaminylation dynamics are regulated by a single enzyme and promote neural rhythmicity
Histone H3 monoaminylations at glutamine(Q) 5 represent an important family of epigenetic markers in neurons that play critical roles in the mediation of permissive gene expression (1, 2). We previously demonstrated that H3Q5 serotonylation(ser) and dopaminylation(dop) are catalyzed by the Transglut...
ORGANISM(S): Homo sapiens (Human) 
2024-10-10 | PXD053788 | Pride
Tgm2 Bidirectionally controls h3 monoaminylation dynamics Which Facilitate neural rhythmicity. In turn A single enzyme 
UnknownDirect oral anticoagulants versus vitamin K antagonists after recent ischemic stroke in patients with atrial fibrillation.
Not available
S-EPMC6563449 | biostudies-literature
UnknownDescription of Lentistivalius philippinensis, a new species of flea (Siphonaptera, Pygiosyllomorpha, Stivaliidae), and new records of Ascodipterinae (Streblidae) on bats and other small mammals from Luzon, The Philippines.
Not available
S-EPMC3591773 | biostudies-literature
UnknownMyxofibrosarcoma harboring an MLH1 pathogenic germline variant associated with Muir-Torre syndrome: a case report.
Not available
S-EPMC8379813 | biostudies-literature
UnknownGenetic contribution to radiographic severity in osteoarthritis of the knee.
Not available
S-EPMC3414227 | biostudies-literature
UnknownPoor Patient Care Outcomes and Nurse Job Outcomes Associated With Unfavorable Intensive Care Unit and Emergency Department Nurse Work Environments: Implications for Critical Care Medicine.
Not available
S-EPMC12372961 | biostudies-literature
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