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ProteomicsStructural mechanism of γ-carboxylation coupled to vitamin K epoxidation at membrane interface
Hemostasis and various non-hemostatic physiologies require γ-carboxylation of designated glutamates in vitamin K-dependent proteins (VKDPs), a process coupled with epoxidation of vitamin K hydroquinone (KH2) by membrane-integrated γ-carboxylase (VKGC). To understand this unique biochemistry, we dete...
ORGANISM(S): Homo sapiens (Human) 
2025-12-22 | PXD052939 | Pride
Factor ix Vitamin k epoxide Vkgc Fix Γ-carboxylation Tmg2 
ProteomicsMolecular basis of vitamin K driven γ-carboxylation at membrane interface
The γ-carboxylation of glutamate residues enables Ca2+-mediated membrane assembly of protein complexes that support broad physiological functions including hemostasis, calcium homeostasis, immune response, and endocrine regulation. Modulating γ-carboxylation level provides prevalent treatments for h...
ORGANISM(S): Homo sapiens (Human) 
2026-01-26 | PXD059315 | Pride
Human Electron microscopy Cryo-em Post-translational modifications Lc-ms/ms 
ProteomicsIdentification of vitamin K-dependent proteins in mouse liver by LC-MS/MS
Vitamin K (VK), a fat-soluble vitamin, functions as a co-factor during the gamma-carboxylation reaction that converts glutamic acid residues to gamma-carboxyglutamic acid residues in proteins transiting through the endoplasmic reticulum. Two enzymes are involved which together form the VK cycle: gam...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD032920 | Pride
Gamma-carboxylation Mouse Liver Vitamin k Lc-ms/ms 
ProteomicsIdentification of gamma-carboxyglutamic acid residues in mouse ERGP by LC-MS/MS.
Vitamin K (VK) is a micronutrient required for the gamma-carboxylation of secreted proteins. Clinical studies have recently implicated VK in the pathophysiology of diabetes. Our data indicate that rodent beta-cells lacking gamma-carboxylation fail to adapt their insulin secretion in response to gluc...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD032955 | Pride
Junctate Gamma-carboxylation Mouse Vitamin k Lc-ms/ms 
UnknownInvestigation and identification of protein γ-glutamyl carboxylation sites.
Not available
S-EPMC3278826 | biostudies-literature
UnknownAbsence of Vitamin K-Dependent γ-Carboxylation in Human Periostin Extracted from Fibrotic Lung or Secreted from a Cell Line Engineered to Optimize γ-Carboxylation.
Not available
S-EPMC4537219 | biostudies-literature
UnknownMolecular basis of vitamin-K-driven γ-carboxylation at the membrane interface.
Not available
S-EPMC12701776 | biostudies-literature
UnknownStructural insights into the vitamin K-dependent γ-carboxylation of osteocalcin.
Not available
S-EPMC12484842 | biostudies-literature
UnknownGamma-carboxylation and fragmentation of osteocalcin in human serum defined by mass spectrometry.
Not available
S-EPMC4458719 | biostudies-literature
Unknowngamma -Glutamyl carboxylation: An extracellular posttranslational modification that antedates the divergence of molluscs, arthropods, and chordates.
Not available
S-EPMC122178 | biostudies-literature
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