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ProteomicsStructural mechanism of γ-carboxylation coupled to vitamin K epoxidation at membrane interface
Hemostasis and various non-hemostatic physiologies require γ-carboxylation of designated glutamates in vitamin K-dependent proteins (VKDPs), a process coupled with epoxidation of vitamin K hydroquinone (KH2) by membrane-integrated γ-carboxylase (VKGC). To understand this unique biochemistry, we dete...
ORGANISM(S): Homo sapiens (Human) 
2025-12-22 | PXD052939 | Pride
Factor ix Vitamin k epoxide Vkgc Fix Γ-carboxylation Tmg2 
ProteomicsMolecular basis of vitamin K driven γ-carboxylation at membrane interface
The γ-carboxylation of glutamate residues enables Ca2+-mediated membrane assembly of protein complexes that support broad physiological functions including hemostasis, calcium homeostasis, immune response, and endocrine regulation. Modulating γ-carboxylation level provides prevalent treatments for h...
ORGANISM(S): Homo sapiens (Human) 
2026-01-26 | PXD059315 | Pride
Human Electron microscopy Cryo-em Post-translational modifications Lc-ms/ms 
UnknownStructural insights into the vitamin K-dependent γ-carboxylation of osteocalcin.
Not available
S-EPMC12484842 | biostudies-literature
UnknownMolecular basis of vitamin-K-driven γ-carboxylation at the membrane interface.
Not available
S-EPMC12701776 | biostudies-literature
TranscriptomicsCAGE-Seq of gonads and carcasses from D. melanogaster and D. pseudoobscura
We performed CAGE-Seq on dissected ovaries and testes as well as female and male carcasses of two species of Drosophila (D. melanogaster and D. pseudoobscura). These data are used to map transcription start sites. For data usage terms and conditions, please refer to http://www.genome.gov/27528022 ...
ORGANISM(S): Drosophila melanogaster 
2015-02-26 | E-GEOD-66284 | biostudies-arrayexpress
Genomicsdataset_A118845B - samples
Whole genome sequencing for single cells for library A118845B 1209 cells; filetype=bam
EGAD00001007098 | EGA
TranscriptomicsLate chick lung development
Type IV collagen is the main component of the basement membrane which gives strength to the blood-gas barrier. In avians the formation of the blood-gas barrier happens rapidly and before hatching. We have performed a microarray expression analysis in late chick lung development and found that COL4A1...
ORGANISM(S): Gallus gallus 
2015-11-01 | E-GEOD-72385 | biostudies-arrayexpress
ProteomicsLysyl hydroxylase 3 mediated post-translational modifications are required for proper biosynthesis of collagen a1a1a2(IV)
We performed proteomic identification of type IV collagen gel bands from wild-type and lysyl hydroxylase 3 knockout cells by LC-MS after trypsin digestion.
ORGANISM(S): Mus Musculus (mouse) 
2022-11-21 | PXD035051 | JPOST Repository
TranscriptomicsSelf-maintenance of rat C6 glioma stem cells (GSCs) by their non-GSC progenies
Analysis of Hoechst 33342 dye-effluxing side population cells (SP cells defined as glioma stem cells, GSCs) and dye-retaining main population cells (MP cells defined as non-GSCs) that were FACS-sorted from the C6 glioma cell line stably expressing EGFP (C6-eGFP). ECM-related genes, such as Col4a1 an...
ORGANISM(S): Rattus norvegicus 
2016-07-03 | E-GEOD-72431 | biostudies-arrayexpress
TranscriptomicsDehydration impaired normal renal development in infant mice
The kidney is a major organ in which fluid balance and waste excretion is regulated. To obtain mature functions of the kidney, normal renal developmental processes need to be preceded. Comprehensive genetic programs underlying renal development during prenatal life have been widely studied. However,...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-75604 | biostudies-arrayexpress
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