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ProteomicsBorrelia burgdorferi infected Ixodes scapularis nymph saliva proteome
Lyme disease (LD) is one of the most important human vector-borne diseases in North America. Since transmission of Borrelia burgdorferi (Bb), the causative agent of LD, is influenced by yet unknown tick saliva proteins (TSP), the discovery and characterization of such TSPs are highly sought after fo...
ORGANISM(S): Ixodes scapularis (Black-legged tick) (Deer tick) Borreliella burgdorferi Oryctolagus cuniculus (Rabbit) 
2021-09-10 | PXD023940 | Pride
Borrelia burgdorferi Rabbit host Tick saliva 
ProteomicsTime-resolved proteomic profile of Amblyomma americanum tick saliva during feeding Running Title: Proteins in tick saliva every 24 h during feeding
Pioneering studies (PXD014844) have identified many interesting molecules by LC-MS/MS proteomics, but the protein databases used to assign mass spectra were based on short Illumina reads of the Amblyomma americanum transcriptome and may not have captured the diversity and complexity of longer transc...
ORGANISM(S): Amblyomma americanum 
2020-01-23 | PXD014844 | Pride
Tick-feeding Ticks Saliva Proteome 
ProteomicsTick host range adaptation: changes in protein profiles in Ixodes scapularis and Amblyomma americanum saliva during stimulation to feed on different hosts
Understanding the molecular basis of how the tick adapts to feed on different animal hosts is central to understanding tick and tick-borne disease (TBD) epidemiology. Tick adaptation to feed on vertebrate hosts is regulated by tick secretion of multiple tick saliva proteins (TSPs) and other molecule...
ORGANISM(S): Ixodes scapularis (Black-legged tick) (Deer tick) Amblyomma americanum 
2022-02-28 | PXD007712 | Pride
Tick-host relationship Saliva Tick Proteomic Host adaptation 
ProteomicsIdentification and characterization of proteins that form the inner core Ixodes scapularis tick attachment cement layer.
Ixodes scapularis and other hard ticks are long-term blood feeders. This feeding behavior is facilitated by a tick secreted bio adhesive (tick cement) that attaches tick mouthparts to skin tissue and prevents the host from dislodging the tick from its feeding site. Understanding tick cement formatio...
ORGANISM(S): Ixodes scapularis (Black-legged tick) (Deer tick) Oryctolagus cuniculus (Rabbit) 
2023-03-11 | PXD038685 | Pride
Ixodes scapularis tick cement Laser capture micro dissection Lc-ms/ms 
ProteomicsIxodes Scapularis tick saliva proteins sequentially secreted every 24h during blood feeding
Ixodes scapularis is the most medically important tick species and transmits five of the 14 reportable human tick borne diseases (TBD) in the USA. This study describes LC-MS/MS identification of 582 tick- and 83 rabbit proteins in saliva of I. scapularis ticks that fed for 24, 48, 72, 96, and 120h, ...
ORGANISM(S): Ixodes scapularis (Black-legged tick) (Deer tick) 
2015-12-11 | PXD003214 | Pride
Tick feeding physiology Tick saliva proteome Ixodes scapularis 
ProteomicsTuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responses [metabolomics]
Tuberculosis (TB) remains a major public health problem and we lack a comprehensive understanding of how Mycobacterium tuberculosis (M. tb) infection impacts host immune responses. We compared, at two timepoints, the induced immune response to TB antigen, BCG and IL-1β stimulation between latently M...
ORGANISM(S): Homo sapiens 
2022-11-05 | E-MTAB-12381 | biostudies-arrayexpress
TranscriptomicsTuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responses
Tuberculosis (TB) remains a major public health problem and we lack a comprehensive understanding of how Mycobacterium tuberculosis (M. tb) infection impacts host immune responses. We compared, at two timepoints, the induced immune response to TB antigen, BCG and IL-1β stimulation between latently M...
ORGANISM(S): Homo sapiens 
2022-11-05 | E-MTAB-12379 | biostudies-arrayexpress
TranscriptomicsTuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responses [Luminex]
Tuberculosis (TB) remains a major public health problem and we lack a comprehensive understanding of how Mycobacterium tuberculosis (M. tb) infection impacts host immune responses. We compared, at two timepoints, the induced immune response to TB antigen, BCG and IL-1β stimulation between latently M...
ORGANISM(S): Homo sapiens 
2022-11-05 | E-MTAB-12380 | biostudies-arrayexpress
UnknownTuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responses.
Not available
S-EPMC9795069 | biostudies-literature
UnknownImmune Profiling Enables Stratification of Patients With Active Tuberculosis Disease or Mycobacterium tuberculosis Infection.
Not available
S-EPMC8563210 | biostudies-literature
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