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TranscriptomicsNeutrophil-derived pro-inflammatory cytokine response and degranulation in function of time and dose of LPS treatment.
The purpose of the present study was to elucidate in more details the molecular mechanisms of neutrophil-mediated inflammation. We therefore investigated the time-dependent stimulatory potential of LPS from Escherichia coli on cytokine response in neutrophil-like HL-60 cells.

To get a genera...
ORGANISM(S): Homo sapiens 
2014-12-17 | E-MTAB-1393 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of lymphocytes from patients with B chronic lymphocytic leukemia treated with fludarabine to identify a signature of drug resistance
Identification of a signature of resistance to fludarabine in B chronic lymphocytic leukemia patients in vivo
ORGANISM(S): Homo sapiens 
2009-11-28 | E-MTAB-70 | biostudies-arrayexpress
TranscriptomicsExploration of the mechanisms underlying TNF-alpha resistance in breast cancer cells by a transcriptomic approach using an autophagy-dedicated microarray.
We used the autophagy microarray to profile the transcriptome of well-characterized TNF sensitive MCF-7 cell line and corresponding TNF-resistant 1001 clone.
ORGANISM(S): Homo sapiens 
2011-02-28 | E-MEXP-3074 | biostudies-arrayexpress
TranscriptomicsDynamic regulation of microRNA expression following Interferon-gamma-induced gene transcription
MicroRNAs are major regulators of post-transcriptional gene regulation. Even small changes in miRNA levels may have profound consequences for the expression levels of target genes. Hence, miRNAs themselves need to be tightly, albeit dynamically, regulated. Here, we investigated the dynamic behaviour...
ORGANISM(S): Homo sapiens 
2012-08-24 | E-MEXP-3544 | biostudies-arrayexpress
TranscriptomicsRepeated systemic challenge with lipopolysaccharides induces dopaminergic neurodegeneration in the brain by activation of the complement-phagosome pathway
Systemic inflammatory reactions mediated by chronic infections activate microglia in the central nervous system (CNS) and have been postulated to exacerbate neurodegenerative diseases. We now demonstrate in vivo that repeated systemic challenge of mice with bacterial lipopolysaccharides (LPS) mainta...
ORGANISM(S): Mus musculus 
2014-07-11 | E-MTAB-1770 | biostudies-arrayexpress
TranscriptomicsBronchial Airway Gene Expression in Smokers with Lung or Head and Neck Cancer
Cigarette smoking is the major cause of cancers of the respiratory tract, including non-small cell lung cancer (NSCLC) and head and neck cancer (HNC). In order to better understand carcinogenesis of the lung and upper airways, we have compared the gene expression profiles of tumour-distant, histolog...
ORGANISM(S): Homo sapiens 
2014-05-24 | E-MTAB-1690 | biostudies-arrayexpress
TranscriptomicsConstitutive activation of oncogenic PDGFR-mutants found in GIST patients induces receptor mislocalisation and alters PDGFR-A signalling characteristics
Gastrointestinal stomal tumors (GIST) are mainly characterised by the presence of activating mutations in either of the two receptor tyrosine kinases c-KIT and Platelet-derived growth factor receptor-a (PDGFRa). Most mechanistic studies dealing with GIST mutations have focused on c-KIT and far less ...
ORGANISM(S): Homo sapiens 
2015-11-11 | E-MTAB-2101 | biostudies-arrayexpress
TranscriptomicsHIV co-receptor usage determines specific miRNA modulations in T-lymphocytes.
HIV-1 and HIV-2 are two etiological agents of Acquired Immune Deficiency Syndrome (AIDS). Several differences exist between these two retroviruses in terms of geographical distribution, replication, transmission and progression to AIDS. The molecular reasons explaining these features are largely unk...
ORGANISM(S): Homo sapiens 
2012-03-06 | E-MEXP-3139 | biostudies-arrayexpress
TranscriptomicsL-plastin Ser5 phosphorylation via RSKs, downstream effectors of the MAPK/ERK pathway, in (breast) cancer cells (and in vitro)
Deregulated cell migration and invasion, which are hallmarks of metastatic cancer cells, are correlated to structural and functional alterations of the actin cytoskeleton associated to a large panel of actin-binding proteins. Among these, the actin-bundling protein L-plastin, initially detected in l...
ORGANISM(S): Homo sapiens 
2016-03-26 | E-MTAB-3487 | biostudies-arrayexpress
TranscriptomicsOncogenic FIP1L1-PDGFR-alpha signaling: influence of subcellular localisation and unconventional STAT activation
Aberrant activation of oncogenic kinases is frequently observed in human cancers, but the underlying mechanism and resulting effects on global signaling are incompletely understood. Here, we demonstrate that the oncogenic FIP1L1-PDGFRa kinase exhibits a significantly different signaling pattern comp...
ORGANISM(S): Homo sapiens 
2015-11-11 | E-MTAB-2102 | biostudies-arrayexpress
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