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ProteomicsHsp multichaperone complex buffers pathologically modified Tau
Alzheimer's disease is a neurodegenerative disorder in which misfolding and aggregation of pathologically modified Tau is critical for neuronal dysfunction and degeneration. The two central chaperones Hsp70 and Hsp90 coordinate protein homeostasis, but the nature of the interaction of Tau with the H...
ORGANISM(S): Homo sapiens (Human) 
2022-08-11 | PXD032037 | Pride
Tau Hsp Multichaperone Alzheimer´s disease 
UnknownHsp multichaperone complex buffers pathologically modified Tau.
Not available
S-EPMC9237115 | biostudies-literature
UnknownA multichaperone condensate enhances protein folding in the endoplasmic reticulum.
Not available
S-EPMC12431857 | biostudies-literature
UnknownAlpha-crystallin-type heat shock proteins: socializing minichaperones in the context of a multichaperone network.
Not available
S-EPMC120782 | biostudies-literature
ProteomicsGlobal Analysis of Protein Folding Thermodynamics for Disease State Characterization, MCF7 vs MDAMB231
Protein biomarkers can be used to characterize and diagnose disease states such as cancer. They can also serve as therapeutic targets. Current methods for protein biomarker discovery, which generally rely on the large-scale analysis of gene and/or protein expression levels, fail to detect protein b...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080761 | MassIVE
ProteomicsGlobal Analysis of Protein Folding Thermodynamics for Disease State Characterization, MCF7 vs MCF10A
Protein biomarkers can be used to characterize and diagnose disease states such as cancer. They can also serve as therapeutic targets. Current methods for protein biomarker discovery, which generally rely on the large-scale analysis of gene and/or protein expression levels, fail to detect protein b...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080760 | MassIVE
UnknownHeat shock protein 60 regulation of the mitochondrial permeability transition pore in tumor cells.
Not available
S-EPMC2982903 | biostudies-literature
UnknownMechanistic basis for a molecular triage reaction.
Not available
S-EPMC5380214 | biostudies-literature
UnknownStructure of an MHC I-tapasin-ERp57 editing complex defines chaperone promiscuity.
Not available
S-EPMC9474470 | biostudies-literature
UnknownCofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system.
Not available
S-EPMC165632 | biostudies-literature
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