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ProteomicsHigh-Throughput Label-free Single-Cell Proteomics Enabled by Multicolumn NanoLC with a 5-min Cycle Time
Mass spectrometry (MS)-based single-cell proteomics (SCP) enables proteome-wide analysis at single-cell resolution, offering insights into cellular heterogeneity, biological processes, and disease mechanisms. However, conventional nanoLC-MS workflows are constrained by long gradients and low through...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-05-21 | PXD070201 | Pride
5-min cycle time 288 spd High-throughput scp Nanolc-ms/ms 
UnknownMulticolumn Nanoflow Liquid Chromatography with Accelerated Offline Gradient Generation for Robust and Sensitive Single-Cell Proteome Profiling.
Not available
S-EPMC11482043 | biostudies-literature
ProteomicsMulticolumn Nanoflow Liquid Chromatography System with Accelerated Offline Gradient Generation for Robust and Sensitive Single-Cell Proteome Profiling
Peptide separations that combine high sensitivity, robustness, peak capacity and throughput are essential for extending bottom-up proteomics to smaller samples including single cells. To this end, we have developed a multicolumn nanoLC system with accelerated offline gradient generation. One binary ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD049248 | Pride
High throughput Proteomics Lc-ms Storage loop Single cell proteomics Multiple columns 
ProteomicsHyperSCP: Combining Isotopic and Isobaric Labeling for Higher Throughput Single-Cell Proteomics
Recent developments in mass spectrometry-based single-cell proteomics (SCP) have resulted in dramatically improved sensitivity, yet the relatively low measurement throughput remains a limitation. Isobaric and isotopic labeling methods have been separately applied to SCP to increase throughput throug...
ORGANISM(S): Homo sapiens (Human) 
2023-07-11 | PXD040455 | Pride
Multiplex Single-cell proteomics High-throughput 
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