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Transgenerational effects likely have wide-ranging implications for human health, biological adaptation and evolution, however their mechanism and biology remain poorly understood. Here we demonstrate that a germline nuclear small RNA/chromatin pathway can maintain epi-allelic inheritance for many g...
ORGANISM(S): Caenorhabditis elegans 
dsRNA-mediated gene silencing (RNAi) can be inherited for multiple generations in C. elegans. To understand this process we conducted a genetic screen for animals defective for transmitting RNAi silencing signals to future generations. This screen identified the gene heritable RNAi defective (hrde)-...
ORGANISM(S): Caenorhabditis elegans 
The notion that genes are the sole units of heredity and that a barrier exists between soma and germline has been a major hurdle in elucidating the heritability of traits that were observed to follow a non-Mendelian inheritance pattern. It was only after the conception of “epigenetics” by C. H. Wadd...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2024-05-10 | PXD037488 | Pride
Transgenerational effects likely have wide-ranging implications for human health, biological adaptation and evolution, however their mechanism and biology remain poorly understood. Here we demonstrate that a germline nuclear small RNA/chromatin pathway can maintain epi-allelic inheritance for many g...
ORGANISM(S): Caenorhabditis elegans 
2012-06-25 | GSE38813 | GEO
Multigenerational DNA methylation responses to copper exposure in Daphnia: potential targets for epigenetic biomarkers?
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