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The physiological role of the spliced form of X-box-binding protein 1 (XBP1s), a key transcription factor of the endoplasmic reticulum (ER) stress response, in adipose tissue remains largely unknown. Here we show that overexpression of XBP1s promotes adiponectin multimerization in adipocytes, thereb...
ORGANISM(S): Mus musculus 
Acetylation-dependent Multimerization of SAGA Regulates Gene Transcription
Lacritin is an abundantly expressed glycoprotein in tear fluid and plays key roles in immune response, tear secretion, and bacterial killing. These biological functions are tightly regulated through several biochemical mechanisms including multimerization, proteolysis, and alternative splicing, espe...
ORGANISM(S): Homo sapiens (Human) 
2026-10-05 | PXD076054 | Pride
Multimerization of ELAV is essential for directing neuronal alternative splicing and polyadenylation programs
Multimerization of MYC shields stalled replication forks from RNA polymerase
Multimerization of MYC shields stalled replication forks from RNA polymerase [BLISS]
The glucocorticoid receptor (GR/NR3C1), a ligand-activated transcription factor belonging to the nuclear receptor (NR) superfamily, is vital for life. Like other NRs, GR features an intrinsically disordered N-terminal domain (NTD) followed by a highly conserved DNA-binding domain (DBD) and a hormone...
ORGANISM(S): Homo sapiens (Human) 
2025-10-27 | PXD065782 | Pride
RNA-mediated MYC multimerization suppresses innate immune signaling [mRNA]
Multimerization of MYC shields stalled replication forks from RNA polymerase [4sU-seq]
In Saccharomyces cerevisiae, the SAGA complex regulates its own activity by undergoing multimerization. This multimerization is triggered by SAGA autoacetylation at three sites on its Ada3 subunit, allowing recognition of this acetylation by the bromodomain of the Gcn5/Spt7 SAGA subunit. Once multim...
ORGANISM(S): Saccharomyces cerevisiae 
2021-11-29 | GSE161887 | GEO
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