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ProteomicsEye opening discoveries: uncovering lacritin glycoforms and the tear fluid glycoproteome
Tear fluid comprises a diverse group of extracellular glycoproteins which are critical for ocular homeostasis. Within the tear fluid glycoproteome, lacritin is highly expressed and plays a key role in immune response, tear secretion, and antimicrobial activity. Importantly, glycosylation constitutes...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD064788 | Pride
Glycoproteomics Mucin Mucinase Lacritin Mass spectrometry Immunoglobulin a Tear fluid 
TranscriptomicsMechanism of lacritin-dependent production of the important dry eye mucin 'MUC16'
Lacritin targets its coreceptor 'syndecan-1' in lacritin-dependent production of the important dry eye mucin 'MUC16'. Real-time PCR analysis suggests that this effect is post-transcriptional. In contrast, serum stimulation of MUC16 by these cells is transcriptionally dependent. Our goal is to determ...
ORGANISM(S): Homo sapiens 
2011-09-06 | GSE31930 | GEO
UnknownLacritin proteoforms prevent tear film collapse and maintain epithelial homeostasis.
Not available
S-EPMC7948570 | biostudies-literature
TranscriptomicsMechanism of lacritin-dependent production of the important dry eye mucin 'MUC16'
Lacritin targets its coreceptor 'syndecan-1' in lacritin-dependent production of the important dry eye mucin 'MUC16'. Real-time PCR analysis suggests that this effect is post-transcriptional. In contrast, serum stimulation of MUC16 by these cells is transcriptionally dependent. Our goal is to det...
ORGANISM(S): Homo sapiens 
2011-09-05 | E-GEOD-31930 | biostudies-arrayexpress
UnknownTear lacritin levels by age, sex, and time of day in healthy adults.
Not available
S-EPMC3460390 | biostudies-literature
UnknownThe Lacritin-Syndecan-1-Heparanase Axis in Dry Eye Disease.
Not available
S-EPMC7398572 | biostudies-literature
UnknownLacritin and other new proteins of the lacrimal functional unit.
Not available
S-EPMC2712882 | biostudies-literature
UnknownIn-depth analysis of the tear fluid glycoproteome reveals diverse lacritin glycosylation and spliceoforms.
Not available
S-EPMC12262445 | biostudies-literature
UnknownIn-depth analysis of the tear fluid glycoproteome reveals diverse lacritin glycosylation and spliceoforms.
Not available
S-EPMC12450620 | biostudies-literature
UnknownLacritin and other autophagy associated proteins in ocular surface health.
Not available
S-EPMC4698016 | biostudies-literature
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