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ProteomicsGlycosite mapping and structural dynamics of TIM family immune checkpoints enabled by mucinase SmE
Mucin-domain glycoproteins are densely O-glycosylated and play key roles in a host of biological functions. In particular, the T-cell immunoglobulin and mucin-domain containing family of proteins (TIM-1, 3, 4) decorate immune cells and act as key checkpoint inhibitors in cancer. However, their dense...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-09-27 | PXD039583 | Pride
O-glycoprotein Tim-1 Cancer Mucinase Tim-4 Tim-3 O-glycosylation Immune checkpoint T-cell immunoglobulin and mucin-domain containing Lc-ms/ms Molecular dynamics Mucinome Mucin O-glycoproteomics Mucin domain Checkpoint inhibitor O-glycoprotease 
UnknownGlycoproteomic landscape and structural dynamics of TIM family immune checkpoints enabled by mucinase SmE.
Not available
S-EPMC10550946 | biostudies-literature
UnknownGlycoproteomic landscape and structural dynamics of TIM family immune checkpoints enabled by mucinase SmE.
Not available
S-EPMC9915616 | biostudies-literature
UnknownModulation of neutrophil function by a secreted mucinase of Escherichia coli O157:H7.
Not available
S-EPMC2642718 | biostudies-literature
UnknownPic Protein From Enteroaggregative E. coli Induces Different Mechanisms for Its Dual Activity as a Mucus Secretagogue and a Mucinase.
Not available
S-EPMC7705071 | biostudies-literature
ProteomicsUnraveling O-Glycan Diversity of Mucins: Insights from SmE Mucinase and Ultraviolet Photodissociation Mass Spectrometry
Data, figures, and tables of O-glycopeptides of TIM-1, MUC-16, and MUC-1 digested with SmE mucinase and activated with ultraviolet photodissociation.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-04-15 | MSV000094544 | MassIVE
UnknownCharacterization of Glycosylation-Specific Systemic and Mucosal IgA Antibody Responses to Escherichia coli Mucinase YghJ (SslE).
Not available
S-EPMC8718676 | biostudies-literature
UnknownSslE elicits functional antibodies that impair in vitro mucinase activity and in vivo colonization by both intestinal and extraintestinal Escherichia coli strains.
Not available
S-EPMC4014459 | biostudies-literature
ProteomicsOptimized mucin-selective enrichment strategy to probe the mucinome
Mucin-domain glycoproteins are densely O-glycosylated and play critical roles in a host of biological functions. Previously, we developed a mucin-selective enrichment strategy by employing a catalytically inactive mucinase (StcE) conjugated to solid support. While this method was effective, it suffe...
ORGANISM(S): Homo sapiens (Human) 
2024-04-10 | PXD046534 | Pride
Mass spectrometry Proteomics Glycoproteomics Mucins Enrichment 
ProteomicsRevealing the human cancer-associated mucinome
Mucin domains are densely O-glycosylated modular protein domains found in a wide variety of cell surface and secreted proteins. Mucin-domain glycoproteins are key players in a host of human diseases, especially cancer, but the scope of the mucinome remains poorly defined. Recently, we characterized ...
ORGANISM(S): Homo sapiens (Human) 
2022-06-29 | PXD024995 | Pride
Mucin Cancer Mucinase Proteomics Mucinome Mass spectrometry Glycoproteomics O-glycosylation 
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