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ProteomicsRevealing the human cancer-associated mucinome
Mucin domains are densely O-glycosylated modular protein domains found in a wide variety of cell surface and secreted proteins. Mucin-domain glycoproteins are key players in a host of human diseases, especially cancer, but the scope of the mucinome remains poorly defined. Recently, we characterized ...
ORGANISM(S): Homo sapiens (Human) 
2022-06-29 | PXD024995 | Pride
Mucin Cancer Mucinase Proteomics Mucinome Mass spectrometry Glycoproteomics O-glycosylation 
UnknownRevealing the human mucinome.
Not available
S-EPMC9209528 | biostudies-literature
UnknownMass Spectrometry-Compatible Elution Technique Enables an Improved Mucin-Selective Enrichment Strategy to Probe the Mucinome.
Not available
S-EPMC12050071 | biostudies-literature
ProteomicsOptimized mucin-selective enrichment strategy to probe the mucinome
Mucin-domain glycoproteins are densely O-glycosylated and play critical roles in a host of biological functions. Previously, we developed a mucin-selective enrichment strategy by employing a catalytically inactive mucinase (StcE) conjugated to solid support. While this method was effective, it suffe...
ORGANISM(S): Homo sapiens (Human) 
2024-04-10 | PXD046534 | Pride
Mass spectrometry Proteomics Glycoproteomics Mucins Enrichment 
ProteomicsScreening of the transcriptome, mucinome, and O‐/N‐glycans of the intestinal goblet cell model HT29‐MTX during zinc deficiency
Zinc deficiency is a global health problem affecting approximately one billion people and is associated with serious health consequences, including impaired immune function and an increased susceptibility to infections and inflammation. It is also linked to disrupted intestinal homeostasis and a hig...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD080424 | Pride
Glycosylation Mucinome Goblet cell Zinc deficiency 
UnknownDisplay of the human mucinome with defined O-glycans by gene engineered cells.
Not available
S-EPMC8249670 | biostudies-literature
ProteomicsDisplay of the Human Mucinome with Defined O-Glycans by Gene Engineered Cells
Mucins are a large family of heavily O-glycosylated proteins that cover all mucosal surfaces and constitute the major macromolecules in most body fluids. Mucins can form aggregated networks and bundles that serve as a barrier, but also assist in containing, feeding, clearing and replenishing microor...
ORGANISM(S): Homo sapiens (Human) 
2021-05-11 | PXD024851 | Pride
Glycosylation Orbitrap Intact mass Mucin 
ProteomicsGlycosite mapping and structural dynamics of TIM family immune checkpoints enabled by mucinase SmE
Mucin-domain glycoproteins are densely O-glycosylated and play key roles in a host of biological functions. In particular, the T-cell immunoglobulin and mucin-domain containing family of proteins (TIM-1, 3, 4) decorate immune cells and act as key checkpoint inhibitors in cancer. However, their dense...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-09-27 | PXD039583 | Pride
O-glycoprotein Tim-1 Cancer Mucinase Tim-4 Tim-3 O-glycosylation Immune checkpoint T-cell immunoglobulin and mucin-domain containing Lc-ms/ms Molecular dynamics Mucinome Mucin O-glycoproteomics Mucin domain Checkpoint inhibitor O-glycoprotease 
UnknownGlycoproteomic landscape and structural dynamics of TIM family immune checkpoints enabled by mucinase SmE.
Not available
S-EPMC10550946 | biostudies-literature
UnknownGlycoproteomic landscape and structural dynamics of TIM family immune checkpoints enabled by mucinase SmE.
Not available
S-EPMC9915616 | biostudies-literature
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