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MetabolomicsSerum protein N-glycosylation changes in multiple myeloma

BACKGROUND: Multiple myeloma is characterized by clonal proliferation of malignant plasma cells in the bone marrow that produce monoclonal immunoglobulins. N-glycosylation changes of these monoclonal immunoglobulins have been reported in multiple myeloma, but previous studies on...

2022-04-27 | MTBLS676 | MetaboLights
MetabolomicsComparative metabolomics and transcriptomics revealed multiple pathways associated with polymyxin killing in Pseudomonas aeruginosa
Polymyxins are the last-line antibiotics against multidrug-resistant Pseudomonas aeruginosa however, resistance to polymyxins has been increasingly reported. Therefore, understanding the mechanisms of polymyxin activity and resistance is crucial for preserving their clinical usefulness. This study e...
2018-11-14 | MTBLS751 | MetaboLights
MetabolomicsChanges in Amino Acid and Acylcarnitine Plasma Profiles for Distinguishing Patients with Multiple Sclerosis from Healthy Controls
McDonald criteria and magnetic resonance imaging (MRI) are used for the diagnosis of multiple sclerosis (MS); nevertheless, it takes a considerable amount of time to make a clinical decision. Amino acid and fatty acid metabolic pathways are disturbed in MS, and this information could be useful for d...
2022-05-24 | MTBLS704 | MetaboLights
MetabolomicsAcute response to a high-saturated, high-refined carbohydrate meal in healthy young men shows novel perturbation of multiple metabolic and defense pathways

Regular consumption of fat and refined carbohydrates induces metabolic stress, increasing chronic metabolic disease risk. In healthy volunteers, we characterised the response to a high-fat/high-carbohydrate meal (HFHCM), typical of an ultra-processed food, by proteomic and metabolomics analyses, ...

2026-04-02 | MTBLS10972 | MetaboLights
MetabolomicsNanoinducers-mediated Mitochondria-Selective Degradation Enhance T Cell Immunotherapy Against Multiple Cancers

Cancer immunotherapy utilizing cytotoxic T lymphocytes (CTLs) has demonstrated significant promise in clinical applications, but cancer immunosuppressive mechanisms hamper further progress in T cell immunotherapy. Here we show a correlation between cancer cell mitochondria content and their resis...

2025-03-13 | MTBLS12284 | MetaboLights
MetabolomicsInteraction of Genetic Variants Activates Latent Metabolic Pathways in Yeast

Genetic interactions are fundamental to the architecture of complex traits, yet the molecular mechanisms by which variant combinations influence cellular pathways remain poorly understood. Here, we answer the question of whether interactions between genetic variants can activate unique pathways a...

2025-07-22 | MTBLS12761 | MetaboLights
MetabolomicsUltrasound Priming Enhances Seed Vigor and Multiple Stresses Tolerance in Aged Maize Seeds

Seed aging leads to reduced germination rates and vigor, particularly under stress conditions. We subjected aged maize seeds to 40 seconds of ultrasonic treatment, which enhanced their vigor and tolerance to combined stress. The ultrasonic treatment increased more cracks and holes in the seed coa...

2026-03-25 | MTBLS14138 | MetaboLights
MetabolomicsAdipocyte-derived β-hydroxybutyrate confers metabolic resilience in multiple myeloma by stabilizing IRF4 via NAT10-mediated acetylation

Multiple myeloma (MM) remains an incurable hematologic malignancy despite advances in treatment. While obesity is a well-established risk factor, the underlying metabolic mechanisms by which adipocytes contribute to disease progression remain elusive. Here, we uncover a critical m...

2026-05-07 | MTBLS14445 | MetaboLights
MetabolomicsUltrasound Priming Enhances Seed Vigor and Multiple Stresses Tolerance in Aged Maize Seeds
Seed vigor plays a crucial role in germination rate, population uniformity, seedling stress resistance and potential yield at maturity. Here we report a simple, eco-friendly physical method (40-second ultrasound) that rapidly triggers aged seeds to enhance seed vigor and stress resistance. Significa...
2026-07-15 | MTBLS15047 | MetaboLights
MetabolomicsAlignment of multiple metabolomics LC-MS datasets from disparate diseases to reveal fever-associated metabolites

Acute febrile illnesses are still a major cause of mortality and morbidity globally, particularly in low to middle income countries. The aim of this study was to determine any possible metabolic commonalities of patients infected with disparate pathogens that cause fever. Three liquid chromatogra...

2023-07-17 | MTBLS4895 | MetaboLights
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