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MetabolomicsExercise-Associated Microbial Metabolites Prevent Skeletal Muscle Atrophy in Adult Mice
We previously reported that skeletal muscle adaptation to regular exercise requires a healthy gut microbiome, contributing to growing evidence that some exercise benefits are mediated by microbiome-derived metabolites. Here, to identify such exercise-associated microbial metabolites, we transfer cec...
2026-05-27 | MTBLS14386 | MetaboLights
MetabolomicsSMN deficiency perturbs monoamine neurotransmitter metabolism in spinal muscular atrophy

Beyond motor neuron degeneration, homozygous mutations in the survival motor neuron 1 (SMN1) gene cause multiorgan and metabolic defects in patients with spinal muscular atrophy (SMA). However, the precise biochemical features of these alterations and the age of onset in the brain and peripheral ...

2023-11-27 | MTBLS8784 | MetaboLights
TranscriptomicsmRNA microarray analysis of the substantia nigra in a mouse model of multiple system atrophy
Multiple system atrophy (MSA) is a fatal rapidly progressive α-synucleinopathy, characterized by prominent α-synuclein accumulation in oligodendrocytes. In this study we investigated mRNA expression in substantia nigra of MSA transgenic mice (Tg(Plp1-SNCA)1Haa) and wild type controls. This forms p...
ORGANISM(S): Mus musculus 
2016-03-15 | E-MTAB-3985 | biostudies-arrayexpress
TranscriptomicsmiRNA microarray analysis of the substantia nigra and stratum in a mouse model of multiple system atrophy
Multiple system atrophy (MSA) is a fatal rapidly progressive α-synucleinopathy, characterized by prominent α-synuclein accumulation in oligodendrocytes. In this study we used Exiqon microarrays to investigate micro RNA expression in substantia nigra and striatum of MSA transgenic mice (Tg(Plp1-SNC...
ORGANISM(S): Mus musculus 
2016-03-15 | E-MTAB-3986 | biostudies-arrayexpress
TranscriptomicsmicroRNA profiling by high-throughput sequencing in the substantia nigra and striatum of Multiple System Atrophy (MSA) transgenic mice and wild type controls
Multiple system atrophy (MSA) is a fatal rapidly progressive Ia-synucleinopathy, characterized by prominent Ia-synuclein accumulation in oligodendrocytes. In this study we investigated miRNA expression in the substantia nigra and striatum of MSA transgenic mice (Tg(Plp1-SNCA)1Haa) and wild type cont...
ORGANISM(S): Mus musculus 
2016-03-15 | E-MTAB-3993 | biostudies-arrayexpress
ProteomicsProteome profiling of brain tissue from multiple system atrophy patients and from controls
Human brain tissue was collected post mortem from patients diagnosed with multiple system atrophy (n=45) and from controls (n=30) in order to perform a comparative quantitative proteome profiling of tissue from the prefrontal cortex (Broadman area 9).
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD026370 | Pride
Human Q-exactive hf-x Prefrontal cortex Mass spectrometry Brain tissue Multiple system atrophy Proteome 
ProteomicsGadd45a Promotes Skeletal Muscle Atrophy by Forming a Complex with the Protein Kinase MEKK4
Skeletal muscle atrophy is a serious and highly prevalent condition that remains poorly understood at the molecular level. Previous work found that skeletal muscle atrophy involves an increase in skeletal muscle Gadd45a expression, which is necessary and sufficient for skeletal muscle fiber atrophy...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2016-05-17 | MSV000079730 | MassIVE
ProteomicsPost-translational modifications of MSA alpha-synuclein
LC-MS/MS analysis of post-translational modifications in alpha-synuclein of five MSA cases.
ORGANISM(S): Homo Sapiens (human) 
2020-04-09 | PXD018434 | JPOST Repository
GenomicsRNA-seq in putamen of Multiple system atrophy patients
RNA-seq in putamen of Multiple system atrophy patients
PRJNA555211 | ENA
UnknownSensitivity to Change and Patient-Centricity of the Unified Multiple System Atrophy Rating Scale Items: A Data-Driven Analysis.
Not available
S-EPMC9543676 | biostudies-literature
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