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ProteomicsIntegrative proteomic and transcriptomic profiling identifies unique and shared functions of oncogenic KRAS and RIT1
Lo A, Holmes K, Mundt F, Moorthi S, Fung I, Fereshetian S, Watson J, Carr SA, Mertins P, Berger A. Aberrant activation of RAS oncogenes is a prevalent event in lung adenocarcinoma, with somatic mutation of KRAS occurring in ~30% of tumors. Recently, we identified somatic mutation of the RAS-family G...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-04-03 | MSV000085225 | MassIVE
ProteomicsProteomics, post-translational modifications, and integrative analyses reveal heterogeneity of molecular mechanisms within medulloblastoma subgroups
Archer TC, Ehrenberger T, Mundt F, Gold MP, Krug K, Mah CK, Mahoney EL, Daniel CJ, LeNail A, Ramamoorthy D, Mertins P, Mani DR, Zhang H, Gillette MA, Clauser K, Noble M, Tang LC, Francois JP, Silterra J, Jensen J, Tamayo P, Korshunov A, Pfister SM, Kool M, Northcott PA, Sears RC, Lipton JO, Carr SA,...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-07-20 | MSV000082644 | MassIVE
UnknownPromoting Safe Injection Practices, Substance Use Reduction, Hepatitis C Testing, and Overdose Prevention Among Syringe Service Program Clients Using a Computer-Tailored Intervention: Pilot Randomized Controlled Trial.
Not available
S-EPMC7556373 | biostudies-literature
ProteomicsIn depth profiling of the cancer proteome from the flowthrough of standard RNA-preparation kits for precision oncology
Cancer tumors are highly heterogeneous, also within the same patient. Biopsies taken from different regions of a tumor may stand in stark molecular contrast to each other. Therefore, the ability to generate meaningful data from multiple platforms using the same biopsy is crucial for translating mult...
ORGANISM(S): Homo sapiens (Human) 
2026-10-05 | PXD041313 | Pride
Human Clinical proteomics Metastases Multi-omcis 
ProteomicsIn depth profiling of the cancer proteome from the flowthrough of standard RNA-preparation kits for precision oncology
Cancer is a highly heterogeneous disease, even within the same patient. Biopsies taken from different regions of a tumor may stand in stark molecular contrast to each other. Therefore, the ability to generate meaningful data from multiple platforms using the same biopsy is crucial for translating mu...
ORGANISM(S): Homo sapiens (Human) 
2026-10-05 | PXD056337 | Pride
Precision oncology Cancer Proteome 
UnknownHow stressful was the COVID-19 pandemic for residents specializing in family practice?. A study of stressors and psychological well-being of physicians in further training specializing in family practice (GP trainees) within a pandemic context.
Not available
S-EPMC9713726 | biostudies-literature
ProteomicsProteomic analysis of different developmental stages of Cystoisospora suis (Apicomplexa: Coccidia) in vitro
The apicomplexan parasite Cystoisospora suis has global significance as an enteropathogen of suckling piglets. Its intricate life cycle entails a transition from an asexual phase to sexual development, ultimately leading to the formation of transmissible oocysts. To advance our understanding of the ...
ORGANISM(S): Cystoisospora suis 
2023-10-13 | PXD045050 | Pride
Swine  apicomplexa  sexual development  proteome  metabolism  oocyst  gametes Isospora suis  coccidia 
ProteomicsOrgan-specific metabolic pathways distinguish prediabetes, type 2 diabetes and normal tissues
Defects in pancreatic islets and the progression of multi-tissue insulin resistance in combination with environmental factors are the main causes of type 2 diabetes (T2D). Mass spectrometry-based proteomics of five key-metabolic tissues on a cohort of 42 multi-organ donors provided deep coverage of ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-12 | PXD027597 | Pride
Pancreatic islets Proteomics Type 2 diabetes Serum Liver Skeletal muscle Visceral adipose tissue (vat) 
ProteomicsMass spectrometry-based proteomics reveals potential roles of NEK9 and MAP2K4 in resistance to PI3K inhibitors in triple negative breast cancer

Filip Mundt, Sandeep Rajput, Shunqiang Li, Kelly Ruggles, Arshag D. Mooradian, Philipp Mertins, Michael A. Gillette, Karsten Krug, et al., Cancer Res. 2018 May 15;78(10):2732-2746. doi: 10.1158/0008-5472.CAN-17-1990.

Activation of phosphoinositide 3-kinase (PI3K) signaling is frequently obs...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-10-19 | MSV000083050 | MassIVE
UnknownPhysical interaction between envelope glycoproteins E and M of pseudorabies virus and the major tegument protein UL49.
Not available
S-EPMC155127 | biostudies-literature
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