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MetabolomicsDesorption electrospray ionisation mass spectrometry imaging of esophageal lymph mode metastases
Lymph node metastases (LNM) and primary tumour samples were analysed using desorption electrospray ionisation mass spectrometry imaging (DESI MSI). Current assessment of LNM depends on subjective histopathological assessment, whereas analysis by DESI MSI permits an entirely objective assessment. The...
2017-01-10 | MTBLS385 | MetaboLights
TranscriptomicsExpression data from pulmonary metastases of clear-cell renal cell carcinoma
The understanding of metastatic spread is limited and molecular mechanisms causing particular characteristics of metastasis, like varying dormancy periods of Mets originating from the same primary tumor entity or the differing number of Mets in patients with the same primary tumor, are largely unkno...
ORGANISM(S): Homo sapiens 
2009-01-13 | E-GEOD-14378 | biostudies-arrayexpress
TranscriptomicsMolecular Profiling of Metastatic Prostate Carcinoma Reveals Substantial Inter-individual and Limited Intra-individual Diversity: Implications for Precision Oncology
Prostate cancers exhibit a spectrum of molecular aberrations of which a substantial subset are amenable to targeted therapeutics. To determine the diversity of somatic alterations present in metastasis within and between individuals we characterized the genomic landscapes of 176 tumors acquired from...
ORGANISM(S): Homo sapiens 
2015-12-18 | E-GEOD-74685 | biostudies-arrayexpress
TranscriptomicsDecreased expression of key tumour suppressor microRNAs is associated with lymph node metastases in triple negative breast cancer
Breast cancer is the most common malignancy that develops in women, responsible for the highest cancer-associated death rates. Triple negative breast cancers (TNBC) represent an important subtype that have an aggressive clinical phenotype, are associated with a higher likelihood of metastasis and ar...
ORGANISM(S): Homo sapiens 
2014-11-24 | E-GEOD-38167 | biostudies-arrayexpress
TranscriptomicsExpression Profile of Primary Colorectal Cancers and associated Liver Metastases
Comparison of expression profiles of primary colorectal cancers with liver metastases of the same patient. Additionally, expression data of normal colon and liver tissue. Abstract of publication will be included upon publication Keywords: expression profiling, colorectal cancer, colon cancer, liver...
ORGANISM(S): Homo sapiens 
2010-07-07 | E-GEOD-14297 | biostudies-arrayexpress
ProteomicsIdentification of a collagen marker in urine improves the detection of colorectal liver metastases
Previously, we reported that a combination of a collagen alpha-1(I) natural occurring peptide (NOP) AGPP(-OH)GEAGKP(-OH)GEQGVP(-OH)GDLGAP(-OH)GP (AGP) and serum carcinoembryonic antigen (CEA) has the potential to detect colorectal liver metastases (CRLM). The combined method needs to be adapted to i...
ORGANISM(S): Homo sapiens (Human) 
2019-11-15 | PXD013533 | Pride
Logistic regression model Colon cancer Colorectal cancer Prm Collagen Colorectal liver metastases Mass spectrometry Natural occurring peptides Urine 
TranscriptomicsGene expression profiling of melanoma brain metastases and matched extracranial metastases
An improved understanding of the molecular pathogenesis of brain metastases, one of the most common and devastating complications of advanced melanoma, may identify and prioritize rational therapeutic approaches for this disease. In particular, the identification of molecular differences between bra...
ORGANISM(S): Homo sapiens 
2014-05-08 | E-GEOD-50493 | biostudies-arrayexpress
ProteomicsSera Protein Signatures of Endometrial Cancer Lymph Node Metastases
sera collected from endometrial cancer patients submitted to direct MS/MS analysis in diluted unprocessed form. MS only analysis of sera has also been performed. files are also available.
ORGANISM(S): Homo Sapiens (human) 
2022-03-17 | PXD031892 | JPOST Repository
TranscriptomicsSRRM4 Expression and the Loss of REST Activity May Promote the Emergence of the Neuroendocrine Phenotype in Castration-Resistant Prostate Cancer
The neuroendocrine (NE) phenotype is associated with the development of metastatic castration-resistant prostate cancer (CRPC). Our objective was to characterize the molecular features of the NE phenotype in CRPC. Expression of chromogranin A (CHGA), synaptophysin (SYP), androgen receptor (AR), and ...
ORGANISM(S): Homo sapiens 
2015-06-24 | E-GEOD-66187 | biostudies-arrayexpress
ProteomicsThe murine metastatic microenvironment of experimental brain metastases in breast cancer differs by host age in vivo: A proteomic study.
Breast cancer in young patients is known to exhibit more aggressive biological behavior and is associated with a less favorable prognosis than the same disease in older patients, owing in part to an increased incidence of brain metastases, the mechanistic explanations behind which remain poorly unde...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2024-01-11 | PXD042346 | Pride
Laser microdissection Mouse model Brain metastases Breast cancer 
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