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TranscriptomicsRNA-seq of porcine peripheral blood mononuclear cells treated with lipopolysaccharide and dexamethasone
RNA-seq analysis was performed following the treatment of porcine PBMCs with lipopolysaccharide and dexamethasone for two hours to investigate responses to acute activation of immune and glucocorticoid receptor signaling and their crosstalk.
ORGANISM(S): Sus scrofa 
2021-11-30 | E-MTAB-9808 | biostudies-arrayexpress
TranscriptomicsTranscriptome responses to dexamethasone of the hypothalamus of pigs with different genotypes at the GRAla610Val mutation
The main aims of the experiment were to 1) chart gene networks governed by glucocorticoid receptor on a genome-wide scale, 2) to provide insights into mechanisms modulating glucocorticoid sensitivity and 3) to obtain better understanding of molecular and phenotypic consequences of the GRAla610Val su...
ORGANISM(S): Sus scrofa 
2021-11-30 | E-MTAB-7494 | biostudies-arrayexpress
TranscriptomicsTranscriptional response to tetanus vaccination in porcine PBMCs
Three groups of German Landrace piglets were vaccinated with tetanus toxoid. Transcriptome profiles of PBMC were analysed from blood samples taken 0, 2, 4, 8, 24 and 75 hours after a first vaccination and 0, 2, 4, 8, 24 and 75 hours as well as 14 d after a second vaccination on day 14. pair wise com...
ORGANISM(S): Sus scrofa 
2012-12-31 | E-GEOD-38602 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of articular cartilage reveals functional pathways and networks of candidate genes for osteochondrosis in pigs
Osteochondrosis disorder is characterized by a failure of endochondral ossification of the articular-epiphyseal cartilage and the physeal growth cartilage. The number and identity of relevant genes are unknown. Simultaneously, 24,123 probe-sets were screened, of which 12,292 had present in at least ...
ORGANISM(S): Sus scrofa 
2013-10-21 | E-GEOD-44991 | biostudies-arrayexpress
TranscriptomicsInvestigating pathogen defense mechanisms of porcine mammary epithelial cells in vitro.
Porcine mammary epithelial cell (PMEC) cultures of three lactating sows were treated with potential mastitis-causing pathogens E. coli and S. aureus in vitro. Subsequently transcriptome profiles were analysed after 3 h and 24 h post-challenge, respectively. per experimental group 3 PMEC cultures wer...
ORGANISM(S): Sus scrofa 
2015-12-18 | E-GEOD-64246 | biostudies-arrayexpress
TranscriptomicsTransriptome responses to dexamethasone in hippocampus of pigs with different genotypes at a glucocorticoid receptor gain-of-function mutation profiled using RNA-Seq
The main aims of the experiment were to 1) chart gene networks governed by glucocorticoid receptor on a genome-wide scale, 2) to provide insights into mechanisms modulating glucocorticoid sensitivity and 3) to obtain better understanding of molecular and phenotypic consequences of the GRAla610Val su...
ORGANISM(S): Sus scrofa 
2021-12-31 | E-MTAB-9098 | biostudies-arrayexpress
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