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ProteomicsCalsequestrins make the difference in adult zebrafish brain
Aim of the study was to examine the expression of calsequestrin isoforms in zebrafish adult brain. By quantitative PCR we found three RNA transcripts coding for Casq1a, Casq1b and Casq2. In brain homogenate, two protein isoforms were detected by western blotting and mass spectrometry. Whole brain fr...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2020-05-27 | PXD015577 | Pride
Calsequestrin Danio rerio Cerebellum Adult 
ProteomicsFunctional abnormalities in iPSC-CMs generated from titin-mutated patients
Dilated cardiomyopathy (DCM), a myocardial disorder that can result in progressive heart failure and arrhythmias, is defined by ventricular chamber enlargement and dilatation, and systolic dysfunction. To decipher the basis for the cardiac pathology in titin-mutated patients, we investigated the hyp...
ORGANISM(S): Homo sapiens (Human) 
2019-04-12 | PXD010513 | Pride
Dilated cardiomyopathy (dcm)  induced pluripotent stem cell-derived (ipsc)  cardiomyocytes  titin mutation  calcium transients and contraction. 
ProteomicsCalsequestrins in skeletal and cardiac muscle from adult Danio rerio.
All vertebrates have multiple genes encoding for different CASQ isoforms. Increasing interest has been focused on mammalian and human CASQ genes since mutations of both cardiac (CASQ2) and skeletal (CASQ1) isoforms cause different, and sometime severe, human pathologies Danio rerio (zebrafish) is a ...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2015-11-10 | PXD002455 | Pride
Cardiac Muscle Skeletal Calsequestrins 
TranscriptomicsSingle-cell RNA-seq of hESC (H9) lines exposed to a striatal differentiation protocol
Use of single-cell transcriptomics to measure how well medium spiny projection neurons, derived from human ESC, recapitulate human striatal development in vivo. This in vitro single-cell dataset was derived after exposing hESC lines (H9) to a novel striatal differentiation protocol and performing si...
ORGANISM(S): Homo sapiens 
2023-01-31 | E-MTAB-12080 | biostudies-arrayexpress
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