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TranscriptomicsSingle cell transcriptomics analysis of induced pluripotent stem cell-derived cortical neurons reveals frequent dual layer identity
Induced pluripotent stem cell (iPSC)-derived cortical neurons present a powerful new model of neurological disease. Previous work has established that differentiation protocols produce cortical neurons but little has been done to characterise these at cellular resolution. In particular, it is unclea...
ORGANISM(S): Homo sapiens 
2016-01-08 | E-GEOD-69790 | biostudies-arrayexpress
TranscriptomicsRNA-seq of in vitro differentiation of human embryonic stem cells into cortical neurons over 77 days
Many neurological and psychiatric disorders affect the cerebral cortex, and a clearer understanding of the molecular processes underlying human corticogenesis will provide greater insight into such pathologies. To date, knowledge of gene expression changes accompanying corticogenesis is largely base...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-56796 | biostudies-arrayexpress
TranscriptomicssnRNA-seq of cortices from a MCT8-OATP1C1-deficient Allan-Herndon-Dudley Syndrome mouse model
Allan-Herndon-Dudley syndrome (AHDS) is a rare disorder caused by faulty thyroid hormone transport to the brain, leading to severe movement problems and intellectual disability. Our study in a murine model of the AHDS used snRNAseq to gain deep insights into individual cortical cells, aiming to unra...
ORGANISM(S): Mus musculus 
2026-08-07 | E-MTAB-16567 | biostudies-arrayexpress
TranscriptomicsAcutely isolated murine cortical astrocytes and microglia: Alzheimer's disease vs wildtype- effect of gfap-/- and vim-/-
GFAP and vimentin deficiency alters gene expression in astrocytes and microglia in wild-type mice and changes the transcriptional response of reactive glia in mouse model for Alzheimer's disease. Reactive astrocytes with an increased expression of intermediate filament (IF) proteins Glial Fibrillary...
ORGANISM(S): Mus musculus 
2015-11-04 | E-GEOD-74614 | biostudies-arrayexpress
TranscriptomicsE12.5 Murine lateral cortical progenitor cells: Pax6sey/sey vs. Pax6+/+
The mechanisms by which the early spatiotemporal expression patterns of transcription factors such as Pax6 regulate the region-specific proliferation rates of neural progenitors are poorly understood. Pax6 is expressed in a gradient across the developing cortex and is essential for normal corticogen...
ORGANISM(S): Mus musculus 
2013-01-31 | E-GEOD-38703 | biostudies-arrayexpress
TranscriptomicsPatterns of gene expression and evolution in the human developing cerebral cortex
The cerebral cortex underwent a rapid expansion and complexification during recent primate evolution, but the underlying developmental mechanisms remain essentially unknown. In order to uncover genetic networks underlying the development of the human cerebral cortex, we profiled the transcriptome o...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-21858 | biostudies-arrayexpress
GenomicsA Phospho-Regulatory Switch Governs the Timing of Cortical Development
A Phospho-Regulatory Switch Governs the Timing of Cortical Development
PRJNA1449947 | ENA
GenomicsType-I-interferon-responsive microglia shape cortical development and behavior
Type-I-interferon-responsive microglia shape cortical development and behavior
PRJNA724035 | ENA
TranscriptomicsExpression data from Ankrd11Yod/+ and WT embryonic cortical neurospheres
Ankrd11 is a potential chromatin regulator implicated in neural development and autism spectrum disorder (ASD) with no known function in the brain. Here, we show that knockdown of Ankrd11 in developing murine or human cortical neural precursors caused decreased proliferation, reduced neurogenesis, a...
ORGANISM(S): Mus musculus 
2014-11-15 | E-GEOD-63303 | biostudies-arrayexpress
TranscriptomicsGlobal gene profiling comparison between hydrogen sulfide- and N-methyl-D-aspartate-induced neuronal deaths
Hydrogen sulfide (H2S), present in abundance in the mammalian brain, has recently been demonstrated to induce a dose- and time-dependent apoptotic-necrotic continuum in murine primary cortical neurons, which was successfully attenuated upon application of N-methyl-D-aspartate (NMDA) receptor antagon...
ORGANISM(S): Mus musculus 
2013-01-23 | E-GEOD-16035 | biostudies-arrayexpress
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