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MetabolomicsPEROXISOMAL-MITOCHONDRIAL INTERPLAY ALTERATIONS IN SKELETAL MUSCLE RESULT IN EARLY-ONSET SARCOPENIA

Adjustments in muscle mass and metabolic demand are crucial for regulating whole-body metabolism, locomotion, eating, and respiration. Therefore, skeletal muscle is a central influencer of several human diseases. Muscle dysfunction correlates with the onset and progression of several metabolic di...

2025-09-15 | MTBLS12833 | MetaboLights
MetabolomicsSemaglutide targets muscle mitochondria to regulate osteoarthritis

Metabolic and inflammatory diseases often coexist, and become important challenges facing global health, and obesity has shown to be a susceptibility factor for osteoarthritis (OA). As a metabolic regulatory drug for lowering blood sugar and body weight, semaglutide has shown additional therapeut...

2026-05-06 | MTBLS14059 | MetaboLights
MetabolomicsSemaglutide targets muscle mitochondria to regulate glutamine metabolism and treat osteoarthritis

Metabolic and inflammatory diseases often coexist, and become important challenges facing global health, and obesity has shown to be a susceptibility factor for osteoarthritis (OA). As a metabolic regulatory drug for lowering blood sugar and body weight, semaglutide has shown additional therapeut...

2026-05-06 | MTBLS14295 | MetaboLights
TranscriptomicsIsometric contractions in skeletal muscle of adult mice
Study to examine the effect of a demanding 15 minute whole hindlimb isometric contraction protocol in vivo on changes in gene expression, 4 hours post-contraction. Keywords = skeletal muscle Keywords = isometric contractions
ORGANISM(S): Mus musculus 
2010-06-06 | E-GEOD-1679 | biostudies-arrayexpress
ModelsHolmes2006 - Hill's model of muscle contraction
Holmes2006 - Hill's model of muscle contraction This model is described in the article: Teaching from classic papers: Hill's model of muscle contraction. Holmes JW. Adv Physiol Educ 2006 Jun; 30(2): 67-72 Abstract: A. V. Hill's 1938 paper "The heat of shortening and t...
2024-09-02 | BIOMD0000000677 | BioModels
Proteomics,MultiomicsProteomic and Transcriptomic Changes in Hibernating Grizzly Bears Reveal Metabolic and Signaling Pathways that Protect against Muscle Atrophy
Muscle atrophy is a physiological response to disuse and malnutrition, but hibernating bears are largely resistant to this phenomenon. Unlike other mammals, they efficiently reabsorb amino acids from urine, periodically activate muscle contraction, and their adipocytes differentially responds to ins...
ORGANISM(S): Ursus Arctos Horribilis (ncbitaxon:116960) 
2020-01-06 | MSV000084760 | MassIVE
ProteomicsSkeletal Muscle Metabolism of the Astyanax mexicanus
The muscle composition of cave dwelling and surface fish was analyzed by proteomics. Specifically, the composition of the myosin heavy chain was determined by in-gel digestion followed by reversed phase LC-MS/MS. The proteome of the different muscle types was analyzed by tandem mass tags and phosph...
ORGANISM(S): Astyanax Mexicanus (ncbitaxon:7994) 
2021-02-12 | MSV000086857 | MassIVE
TranscriptomicsTranscription profiling of muscles from mice subjected to a single bout of eccentric contractions to understand the molecular mechanism of eccentric contraction-induced injury.
Mice were subjected to 50 eccentric contractions (EC) or 50 isometric contractions (IC) using a non-invasive model, and then sacrificed 48 hours later. RNA from the tibialis anterior of 4 animals were pooled and then split into two groups for hybridization onto two separate Affymetrix MGU74Av2 chips...
ORGANISM(S): Mus musculus 
2007-11-06 | E-GEOD-435 | biostudies-arrayexpress
MetabolomicsMitochondrial NAD+ Deficiency in Vascular Smooth Muscle Impairs Collagen III Turnover to Trigger Aortic Disease

Aortic disease poses a significant mortality risk in adults, yet many of its underlying factors remain undiscovered. In this study, we identify mitochondrial NAD⁺ deficiency as a causal factor. Metabolomics analysis of 73 surgical aortic specimens revealed impaired NAD⁺ salvage and mitochondrial ...

2024-12-04 | MTBLS8062 | MetaboLights
TranscriptomicsTranscription profiling of skeleton muscles recovering at different time points after eccentric contraction and freeze-induced injury to compare the molecular events accompanying the degeneration and repair phases of muscle injuries
Common acute injuries to skeletal muscle can lead to significant pain and disability. The current therapeutic approaches for treating muscle injuries are dependent on the clinical severity but not on the type of injury. The aim of this study was to compare the molecular events accompanying the deg...
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-5413 | biostudies-arrayexpress
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