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MetabolomicsMutation Study
Not available
ORGANISM(S): Arabidopsis thaliana 
ST000013 | MetabolomicsWorkbench
MetabolomicsTissue metabolites in diffuse glioma and their modulations by IDH1 mutation, histology, and treatment
The discovery of the oncometabolite 2-hydroxyglutarate in isocitrate dehydrogenase 1-mutated (IDH1-mutated) tumor entities affirmed the role of metabolism in cancer. However, large databases with tissue metabolites that are modulated by IDH1 mutation remain an area of development. Here, we present a...
2022-09-07 | MTBLS3873 | MetaboLights
MetabolomicsMetabolic alterations caused by the mutation and overexpression of the Tmem135 gene
Mitochondria are highly dynamic organelles undergoing fusion, fission and degradation. Although mitochondria are known to be essential for cellular metabolism, it is not fully understood how mitochondrial dynamics affect cellular metabolism. We previously identified a mouse gene, transmembrane prote...
2021-02-12 | MTBLS1410 | MetaboLights
MetabolomicsMetabolomic profiling of IDH1 mutation
Not available
ORGANISM(S): Homo sapiens 
ST000821 | MetabolomicsWorkbench
MetabolomicsMetabolomic profiling of IDH1 mutation (part II)
Not available
ORGANISM(S): Homo sapiens 
ST000822 | MetabolomicsWorkbench
MetabolomicsReactive Oxygen Species Deficiency Due to Ncf1-Mutation Leads to Development of Adenocarcinoma and Metabolomic and Lipidomic Remodeling in a New Mouse Model of Dextran Sulfate Sodium-Induced Colitis
Inflammatory bowel disease is characterized by chronic relapsing idiopathic inflammation of the gastrointestinal tract and persistent inflammation. Studies focusing on the immune-regulatory function of reactive oxygen species (ROS) are still largely missing. In this study, we analyzed an ROS-deficie...
2019-05-22 | MTBLS593 | MetaboLights
Metabolomicsp53 K316P mutation results in increased liver triglyceride levels and increased rates of de novo lipogenesis.
Not available
ORGANISM(S): Mus musculus 
ST002396 | MetabolomicsWorkbench
TranscriptomicsRNA-Seq Data and Expression Matrices for Brain and Liver from Mice Mutation Accumulation and Control Lines
A mutation accumulation (MA) study was performed on C3H/HeNRj mice for 15-19 generations. At the end of the experiment, brain and liver tissue were extracted from 200 mice from 20 MA lines, and RNA was extracted from each tissue sample, with sequencing performed to achieve an expected coverage of ov...
ORGANISM(S): Mus musculus 
2025-12-14 | E-MTAB-14914 | biostudies-arrayexpress
MetabolomicsMetabolic Profiling of CSF from People Suffering from Sporadic and LRRK2 Parkinson's Disease: A Pilot Study
CSF from unique groups of Parkinson's disease (PD) patients was biochemically profiled to identify previously unreported metabolic pathways linked to PD pathogenesis, and novel biochemical biomarkers of the disease were characterized. Utilizing both 1H NMR and DI-LC-MS/MS we quantitatively profiled ...
2022-09-02 | MTBLS863 | MetaboLights
TranscriptomicsBRAF Mutation Is Rare in Advanced-Stage Low-Grade Ovarian Serous Carcinomas
Low-grade ovarian serous carcinomas are believed to arise via an adenoma-serous borderline tumor-serous carcinoma sequence. In this study, we found that advanced-stage, low-grade ovarian serous carcinomas both with and without adjacent serous borderline tumor shared similar regions of loss of hetero...
ORGANISM(S): Homo sapiens 
2011-03-04 | E-GEOD-27659 | biostudies-arrayexpress
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