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MetabolomicsLignans redress autoimmunity and achieve curative effects on myasthenia gravis by ameliorating the gut microbiome

Myasthenia gravis (MG) is a serious inflammatory autoimmune disease characterized by continuous production of autoantibodies against targets in the neuromuscular junctions, resulting in muscle weakness. Autoimmunity has long been presumed to be irreversible. The current therapeutic regimens may a...

2025-10-24 | MTBLS12842 | MetaboLights
TranscriptomicsTranscription profiling of thymus from myasthenia gravis patients
Identification of deregulated genes in the thymus of myasthenia gravis patients' subgroup.
ORGANISM(S): Homo sapiens 
2006-11-09 | E-MEXP-518 | biostudies-arrayexpress
MetabolomicsDysbiosis of Gut Microbiota and Metabolomic Alterations in Myasthenia Gravis: Insights from 16S rRNA Sequencing and Untargeted Metabolomics

Background: Myasthenia gravis (MG) is an autoimmune disorder of neuromuscular transmission. Gut dysbiosis has been implicated in autoimmune pathogenesis, yet integrated microbial and metabolomic profiling in MG remains scarce.

Objectives:  To characterize gut microbiota and t...

2026-04-13 | MTBLS14266 | MetaboLights
ProteomicsSerum Proteomic Profiling of Myasthenia gravis
The project was focused on the serum proteomic profiling of the neuromuscular autoimmune disease, Myasthenia gravis (MG). The project aimed to identify candidate serum proteins to understand the disease better. To eliminate any typical autoimmune response Rheumatoid arthritis (RA) was included as a ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD019633 | Pride
Rheumatoid arthritis Serum Human Lcmsms Myasthenia gravis Mg Ra 
TranscriptomicsAzathioprine Pharmacogenomics in Myasthenia Gravis Patients
Myasthenia gravis (MG) is an autoimmune disease affecting the neuromuscular junction, whose clinical hallmark is muscle weakness and early fatigability. Azathioprine (AZA) is commonly used in Myasthenia Gravis therapy. AZA is a purine antagonist, which inhibits the cell cycle in the resting and DNA ...
ORGANISM(S): Homo sapiens 
2016-05-01 | E-MTAB-4489 | biostudies-arrayexpress
GenomicGenome-wide Association Study of Myasthenia Gravis

The purpose of this project was to conduct a genome-wide associate study to search for the genetic factors that predispose to myasthenia gravis. The rationale for this study lies in the fact that, although the immunological and physiological processes affecting the neuromuscular junctions of myas...

phs000726 | dbGaP
Genomicsb3103354-894c-4013-9d5d-862135fcebe9 - samples
This dataset contains whole genome sequencing data on 25 individuals with myasthenia gravis. The data was generated using Illumina sequencing technology and is presented as BAM files for each sample.
EGAD00001005262 | EGA
UnknownEfgartigimod Combined with Glucocorticoids in the Treatment of Severe Generalized Myasthenia Gravis: A Single-Center, Retrospective Cohort Study.
Not available
S-EPMC12804567 | biostudies-literature
ProteomicsProteomic profiling identifies ITIH3 as a biomarker for disease activity in myasthenia gravis
Myasthenia gravis (MG) is a chronic antibody-mediated autoimmune disease disrupting neuromuscular synaptic transmission. Antibodies (Abs) against the acetylcholine receptor (AChR) are detected in approximately 85% of patients. Here, we aimed to study the serum proteome of MG and to identify novel bi...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD040786 | Pride
Machine learning Achr Proteomics Treatment response Complement Myasthenia gravis Biomarker Itih 
UnknownCross-sectional analysis of the Myasthenia Gravis Patient Registry: Disability and treatment.
Not available
S-EPMC6899582 | biostudies-literature
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