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TranscriptomicsTranscription profiling of human monocytes infected with adenovirus expressing either c-Myb or v-Myb
The transcriptional activities of c-Myb and its oncogenic variant v-Myb were compared by expressing them in primary human monocytes using recombinant adenovirus vectors. All the samples were compared to cells infected with a control adenovirus expressing only GFP. The results showed that v-Myb, whi...
ORGANISM(S): Homo sapiens 
2007-12-12 | E-GEOD-2816 | biostudies-arrayexpress
Transcriptomicsc-Myb inhibits myoblast fusion
The study of the effects of modification of c-Myb expression on differenatiation of C2C12 cells
ORGANISM(S): Mus musculus 
2013-10-21 | E-MTAB-1376 | biostudies-arrayexpress
TranscriptomicsMicroRNA-15/16 Antagonizes c-Myb to Control Natural Killer Cell Maturation (c-Myb overexpression)
NK cells develop in the bone marrow and complete their maturation in peripheral organs, but the molecular events controlling maturation are incompletely understood. Utilizing an NK cell-specific miR-15/16 deficient genetic model (15aKO), we identified a critical role for miR-15/16 family microRNAs i...
ORGANISM(S): Mus musculus 
2015-09-03 | E-GEOD-58268 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human MCF7 cells infected with adenovirus expressing c-Myb, v-Myb or the hybrid construct, 3MutC
The transcriptional activities of c-Myb and its oncogenic variant v-Myb were compared by expressing them in human MCF7 cells using recombinant adenovirus vectors. A hybrid construct, 3Mutc, which is a variant of c-Myb harboring three v-Myb-derived DNA binding domain mutations was also analyzed. All...
ORGANISM(S): Homo sapiens 
2007-12-12 | E-GEOD-2815 | biostudies-arrayexpress
GenomicsGenome-wide Myb chromatin occupancy in murine myeloid progenitor cells
We report genome-wide pattern of Myb chromatin occupancy in vivo. We used ERMYB, a myeloid progenitor cell line derived by transformation of primary cells by ER-Myb fusion protein, as our model system. In these cells, activation of the ER-Myb fusion protein by estrogen is required to maintain a prol...
ORGANISM(S): Mus musculus 
2011-02-23 | E-GEOD-22095 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila Myb-MuvB/dREAM
Myb-MuvB (MMB)/dREAM is a nine subunit complex first described in Drosophila as a repressor of transcription, dependent upon E2F2 and the RBFs. Myb, an integral member of MMB, curiously plays no role in the silencing of the test genes previously analyzed. Moreover, Myb plays an activating role in DN...
ORGANISM(S): Drosophila melanogaster 
2008-06-16 | E-GEOD-8751 | biostudies-arrayexpress
TranscriptomicsMYB silencing in CD34+ progenitor cells
The c-Myb transcription factor is highly expressed in immature hematopoietic cells and down-regulated during differentiation. To define the role of c-Myb in human hematopoietic lineage commitment, we studied the effects of its silencing during the commitment of human CD34+ Hematopoietic stem/progeni...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-13110 | biostudies-arrayexpress
TranscriptomicsMYB silencing in CD14-myeloblasts
The c-Myb transcription factor is highly expressed in immature hematopoietic cells and down-regulated during differentiation. To define the role of c-Myb during the terminal differentiation of hematopoietic precursors, we studied the effects of its silencing in human primary CD14-myeloblasts, which ...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-21943 | biostudies-arrayexpress
TranscriptomicsExpression Profiling of Erythroid Progenitors After MYB shRNA Knockdown
MYB plays a critical role as a regulator of erythropoieisis. We have shown that MYB silences epsilon and gamma-globin expression in erythroid progenitors. We here examine erythroid cells at the basophilic erythroblast stage of differentiation with MYB shRNA or control lentiviral transduction prior...
ORGANISM(S): Homo sapiens 
2011-01-03 | E-GEOD-25678 | biostudies-arrayexpress
ProteomicsMYB-regulated pancreatic cancer secretome
Earlier we have shown important roles of MYB in pancreatic tumor pathobiology. To better understand the role of MYB in the tumor microenvironment and identify MYB-associated secreted biomarker proteins, we conducted mass spectrometry analysis of the secretome from MYB-modulated and control pancreati...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD015126 | Pride
Pancreatic cancer Myb Biomarkers Secretome 
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