Sort   by:  
 Page size 
ProteomicsLarge bidirectional remodeling of the Myc-induced cell surface proteome in B-cells and prostate cells creates new opportunities for immunotherapy
To identify how MYC overexpression remodels the cell surface proteome in a cell autologous fashion and in different cell types, we investigated the impact of MYC overexpression on ~800 surface proteins in three isogenic model cell lines either of B-cell or prostate cell origin that were engineered t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-08-07 | MSV000085930 | MassIVE
TranscriptomicsDeep sequencing of MYC DNA-binding sites in Burkitt's lymphoma
Background: MYC is a transcription factor encoded by the c-MYC gene (thereafter termed MYC). MYC is key transcription factor involved in many central cellular processes including ribosomal biogenesis. MYC is overexpressed in the majority of human tumours including aggressive B-cell lymphoma especial...
ORGANISM(S): Homo sapiens 
2011-11-28 | E-GEOD-30726 | biostudies-arrayexpress
TranscriptomicsMyc and N-myc induce distinct medulloblastoma subgroups via Miz1
Medulloblastomas (MBs) are cerebellar tumors that can be classified into molecularly distinct subgroups that differ in pathology and prognosis. The mechanisms that underlie subgroup specification are largely unknown. While human SHH MBs express MYCN, Group3 (G3) MBs are associated with c-MYC (MYC) o...
ORGANISM(S): Mus musculus 
2016-01-21 | E-GEOD-66093 | biostudies-arrayexpress
TranscriptomicsThe MYC-MIZ1 interaction defines tumor identity
Medulloblastoma (MB) is the most common malignant brain tumor. MB is a cerebellar tumor that occurs mostly in children between the ages of 3-7 years but also in adults. Human MBs are classified into four subgroups: Wingless (WNT), Sonic Hedgehog (SHH), Group 3 (G3) and G4, each of which with distinc...
ORGANISM(S): Mus musculus 
2016-01-21 | E-GEOD-64425 | biostudies-arrayexpress
TranscriptomicsBone morphogenetic protein-7 is a MYC target with pro-survival functions in childhood medulloblastoma
Medulloblastoma (MB) is the most common malignant brain tumor in children, among whom overexpression or amplification of MYC oncogenes has been associated with poor clinical outcome. Although the MYC functions during normal development and oncogenesis in various systems have been extensively investi...
ORGANISM(S): Homo sapiens 
2011-05-16 | E-GEOD-22139 | biostudies-arrayexpress
TranscriptomicsMYC threshold required to maintain tumor phenotype
We demonstrate that there is a level of MYC expression that is required for maintaining a tumor phenotype and at this threshold there is a switch from a state of cellular proliferation to a state of proliferative arrest and apoptosis. We analyzed changes in gene expression by oligonucleotide microa...
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-10200 | biostudies-arrayexpress
TranscriptomicsMyc-regulated gene expression in human fibroblasts
Myc regulates many gene expression during cell growth, development, or other many cellular events. C-Myc is a well known molecule which expression increase in many cancers. Overexpression of c-Myc causes cell transformation, apoptosis, etc. There are several Myc family genes in human, mouse, or othe...
ORGANISM(S): Homo sapiens 
2010-07-26 | E-GEOD-22654 | biostudies-arrayexpress
no omics definedTranscription profiling of primary mouse keratinocytes infected with Myc, MycV394D or control virus supernatants and treated with or without TGF beta 1 for 12 hours
Primary murine keratinocytes were infected with Myc, MycV394D or control virus supernatants and treated with or without TGF beta 1 for 12 hours. MycV394D is a Myc mutant, which does not bind Miz-1 anymore but is still able to bind to E-box sequences (Mol Cell 10:509-521, 2002).
ORGANISM(S): Mus musculus 
2005-12-20 | E-MEXP-497 | biostudies-arrayexpress
TranscriptomicsExpression data from EμMyc;Prdm11 WT and EμMyc;Prdm11 KO end-stage splenic tumors
The PR-domain family (PRDMs) encodes transcriptional regulators, several of which are deregulated in cancer. We found that loss of Prdm11 accelerates MYC-driven lymphomagenesis in the Eµ-Myc mouse model. Expression data from EμMyc;Prdm11 WT and EμMyc;Prdm11 KO end-stage splenic tumors to identify ge...
ORGANISM(S): Mus musculus 
2015-03-02 | E-GEOD-56063 | biostudies-arrayexpress
TranscriptomicsMyc ChIP in HeLa cells and 2091 fibroblasts
Myc ChIP in HeLa cells and 2091 fibroblasts Keywords: ChIP-chip HeLa cells, quiescent 2091 fibroblasts, and serum stimulated 2091 fibroblasts were used for Myc ChIP reactions.
ORGANISM(S): Homo sapiens 
2008-05-26 | E-GEOD-5197 | biostudies-arrayexpress
Sort   by:  
 Page size