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MetabolomicsGeneration and characterization of thiol-deficient Mycobacterium tuberculosis mutants
Mycothiol (MSH) and ergothioneine (ERG) are thiols able to compensate for each other to protect mycobacteria such as Mycobacterium smegmatis against oxidative stress. Gamma-glutamylcysteine (GGC), another thiol and an intermediate in ERG biosynthesis has detoxification abilities. Five enzymes are in...
2018-07-05 | MTBLS661 | MetaboLights
MetabolomicsRv3400 is a phosphoglucomutase required for trehalose metabolism in Mycobacterium tuberculosis

Mycobacterium tuberculosis is a global killer causing over a million deaths from tuberculosis (TB) every year. It is therefore a major burden on human health. To reduce the deadly impact of TB, we need a better understanding of the strategies used by M. tuberculosis to adapt its...

2026-08-07 | MTBLS13438 | MetaboLights
MetabolomicsMycobacterium tuberculosis VadK required for regulation of the methylcitrate cycle and virulence

The evolution of new enzymatic functions is constrained and guided by the architecture of an organism’s metabolic and regulatory networks and environmental constraints. Here, we identify a kinase that has evolved from pyruvate phosphate dikinase. Through biochemical and systems-lev...

2026-04-21 | MTBLS13906 | MetaboLights
MetabolomicsMetabolomics profiling reveals changes in peptidoglycan and redox metabolism between ancient and modern Mycobacterium tuberculosis

Mycobacterium tuberculosis (Mtb), the cause of tuberculosis, kills over one million people worldwide each year. Mtb is classified into ten distinct lineages, each harboring unique genetic changes that influence its survival, virulence, and transmissibility. Although metabolism plays a cr...

2026-06-26 | MTBLS14029 | MetaboLights
MetabolomicsLsr2, a novel cyclic di-GMP receptor, regulate the synthesis of keto-mycolic acid and control biofilm formation in mycobacteria

Cyclic di-GMP (c-di-GMP) is a well-known second messenger that plays a key role in many physiological processes in bacteria. The synthesis of lipids is essential for bacterial biofilm formation. However, whether c-di-GMP signaling modulates the synthesis of lipid and further regulates biofilm for...

2023-12-12 | MTBLS7053 | MetaboLights
TranscriptomicsComputational drug repositioning identifies niclosamide and tribromsalan as inhibitors of Mycobacterium tuberculosis and Mycobacterium abscessus
Tuberculosis (TB) is still a major global health challenge, killing over 1.5 million people each year, and hence, there is a need to identify and develop novel treatments for Mycobacterium tuberculosis (M. tuberculosis). The prevalence of infections caused by nontuberculous mycobacteria (NTM) is als...
ORGANISM(S): Mycobacterium tuberculosis 
2024-03-01 | E-MTAB-13761 | biostudies-arrayexpress
TranscriptomicsComparison of M. tuberculosis and M. bovis BCG in diluted whole blood cultures
Despite wide scale vaccination with Mycobacterium bovis BCG, the prevalence of tuberculosis remains high, reflecting the global variable efficacy of this vaccine against adult pulmonary TB. Characterisation of different immune responses to M. tuberculosis and M. bovis BCG would increase understandi...
ORGANISM(S): Homo sapiens 
2015-09-10 | E-GEOD-45386 | biostudies-arrayexpress
TranscriptomicsExcessive Cytolytic Responses Predict Tuberculosis Relapse After Apparently Successful Treatment
Background Identification of patients at risk of tuberculosis relapse following treatment would revolutionize clinical trials of new drugs and regimens and facilitate clinical management. The study aim was to determine whether tuberculosis patients who subsequently suffer relapse have different immu...
ORGANISM(S): Homo sapiens 
2015-09-10 | E-GEOD-67589 | biostudies-arrayexpress
TranscriptomicsDual RNA-seq of M. tuberculosis H37Rv infecting macrophage-like THP-1 cells during 48h
Transcriptional changes during early infection of macrophage-like THP-1 cell line with pathogenic bacterium Mycobacterium tuberculosis. RNAseq samples were taken at 0h (THP-1 cells growing in the RPMI medium), and after 4h, 24h and 48h post infection. Bacterial enrichment was performed to increase t...
ORGANISM(S): Homo sapiens 
2017-08-01 | E-MTAB-5287 | biostudies-arrayexpress
TranscriptomicsInducible expression of HigB toxin in Mycobacterium tuberculosis results in growth inhibition, reduced abundance of a subset of mRNAs and cleavage of tmRNA
In this study RNA-seq analysis of M. tuberculosis H37Rv overexpressing HigB compared to the empty vector control strain has been performed in order to investigate the role of the HigB toxin
ORGANISM(S): Mycobacterium tuberculosis 
2013-09-16 | E-MTAB-1667 | biostudies-arrayexpress
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