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TranscriptomicsTranscritpome analysis of Mycobacterium tuberculosis (Mtb) mutants deficient in ergothioneine, or mycothiol production
This experiment was performed to determine deferentially regulated genes in the absence of redox buffer ergothioneine (EGT), or mycothiol (MSH). We had used two Mtb mutants namely egtA:Tn and egtD:Tn which are deficient in EGT production ( Transposon Mutant of EGT biosynthesis pathway); In additi...
ORGANISM(S): Mycobacterium tuberculosis CDC1551 
2016-01-27 | E-MTAB-4099 | biostudies-arrayexpress
ProteomicsMonitoring global protein thiol-oxidation and protein S-mycothiolation in Mycobacterium smegmatis under hypochlorite stress
Mycothiol (AcCys-GlcN-Ins, MSH) is the major thiol-redox buffer in Actinomycetes, including Mycobacterium and Corynebacterium species. ). Protein S-mycothiolation controls the activities of several redox enzymes that function in detoxification of ROS and methionine sulfoxides, including the thiol pe...
ORGANISM(S): Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) 
2017-06-30 | PXD003303 | Pride
Oxicat S-mycothiolation Bacteria Oxidative stress Mycobacterium smegmatis Mycothiol 
MetabolomicsGeneration and characterization of thiol-deficient Mycobacterium tuberculosis mutants
Mycothiol (MSH) and ergothioneine (ERG) are thiols able to compensate for each other to protect mycobacteria such as Mycobacterium smegmatis against oxidative stress. Gamma-glutamylcysteine (GGC), another thiol and an intermediate in ERG biosynthesis has detoxification abilities. Five enzymes are in...
2018-07-05 | MTBLS661 | MetaboLights
UnknownMycothiol synthesis by an anomerization reaction through endocyclic cleavage.
Not available
S-EPMC4778527 | biostudies-literature
UnknownArsenate reductase, mycothiol, and mycoredoxin concert thiol/disulfide exchange.
Not available
S-EPMC2685692 | biostudies-literature
UnknownAn N-acyl homolog of mycothiol is produced in marine actinomycetes.
Not available
S-EPMC2574923 | biostudies-literature
UnknownStructures and mechanisms of the mycothiol biosynthetic enzymes.
Not available
S-EPMC2749902 | biostudies-literature
UnknownMycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis.
Not available
S-EPMC2628429 | biostudies-literature
UnknownIntramolecular alpha-glucosaminidation: synthesis of mycothiol.
Not available
S-EPMC2892847 | biostudies-literature
UnknownIdentification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis.
Not available
S-EPMC5952258 | biostudies-literature
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