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ProteomicsMonitoring of protein thiol-oxidation in S.aureus USA300 under hypochlorite stress using OxICAT approach.
During infections, S. aureus has to cope with the oxidative burst of activated macrophages and neutrophils, including reactive oxygen and nitrogen species (RNS, ROS) and the strong oxidant hypochloric acid. We aimed to understand the global thiol-redox state in the major pathogen S. aureus and disco...
ORGANISM(S): Staphylococcus aureus 
2016-12-22 | PXD004918 | Pride
Oxicat Naocl Gapdh H2o2 Oxidative stress Staphylococcus aureus 
ProteomicsCombining redox proteomics with proximity labeling to monitor localized cysteine oxidation
Reactive oxygen species (ROS) can modulate protein function through cysteine oxidation. Identifying targets of ROS can provide insight into uncharacterized ROS-regulated pathways. Several redox-proteomic workflows, such as OxICAT, exist to identify sites of cysteine oxidation. However, determining R...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-05-21 | PXD034118 | Pride
Cysteine oxidation Apex Reactive oxygen species Oxicat Turboid Proximity labeling 
ProteomicsMonitoring global protein thiol-oxidation and protein S-mycothiolation in Corynebacterium diphtheriae under hypochlorite stress
Mycothiol (AcCys-GlcN-Ins, MSH) is the major thiol-redox buffer in Actinomycetes, including Mycobacterium and Corynebacterium species. Protein S-mycothiolation controls the activities of several redox enzymes that function in detoxification of ROS and methionine sulfoxides, including the thiol perox...
ORGANISM(S): Corynebacterium diphtheriae 
2017-07-17 | PXD003321 | Pride
Oxicat Corynebacterium diphtheria S-mycothiolation Bacteria Oxidative stress Mycothiol 
ProteomicsMonitoring global protein thiol-oxidation and protein S-mycothiolation in Mycobacterium smegmatis under hypochlorite stress
Mycothiol (AcCys-GlcN-Ins, MSH) is the major thiol-redox buffer in Actinomycetes, including Mycobacterium and Corynebacterium species. ). Protein S-mycothiolation controls the activities of several redox enzymes that function in detoxification of ROS and methionine sulfoxides, including the thiol pe...
ORGANISM(S): Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) 
2017-06-30 | PXD003303 | Pride
Oxicat S-mycothiolation Bacteria Oxidative stress Mycobacterium smegmatis Mycothiol 
ProteomicsEffects of the antibacterial compund Allicin from garlic on Escherichia coli
Allicin (diallyl thiosulfinate) from garlic is a highly potent natural antimicrobial substance. It inhibits growth of a variety of microorganisms, among them antibiotic resistant strains. Here, we show that upon exposure to allicin, growth of Escherichia coli is strongly inhibited. Growth inhibition...
ORGANISM(S): Escherichia coli 
2016-05-02 | PXD003063 | Pride
Escherichia coli Allicin Thiol S-allylmercapto 
ProteomicsQuantifying changes in the bacterial thiol redox proteome during host-pathogen interaction
In this study, we used a quantitative redox proteomic method (OxICAT) to assess the in vivo thiol oxidation status of phagocytized E. coli. The majority (65.5%) of identified proteins harbored thiols that were significantly oxidized (>30%) upon phagocytosis. A substantial number of these proteins ar...
ORGANISM(S): Escherichia coli 
2019-01-07 | PXD011386 | Pride
Plb-985 Neutrophils Escherichia coli Redox proteomics 
UnknownRedox proteomics combined with proximity labeling enables monitoring of localized cysteine oxidation in cells.
Not available
S-EPMC10069010 | biostudies-literature
ProteomicsExercise training reverses cancer cachexia-induced decrease in muscle COPS2/TRIP15/ALIEN
The mechanisms underlying exercise-induced effects in the skeletal muscle during cancer cachexia progression have not been fully described. Here, we tested the hypothesis that different exercise training protocols could attenuate metabolic impairment in a severe model of cancer cachexia. Moderate-in...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD013226 | Pride
Cancer cachexia  skeletal muscle wasting  muscle atrophy  endurance exercise  aerobic exercise 
ProteomicsAnalysis of ageing-dependent thiol oxidation reveals early oxidation of proteins involved in core proteostasis functions
Oxidants have a profound impact on biological systems in physiology and under pathological conditions. Oxidative post-translational modifications of protein thiols are well-recognized as a readily occurring alteration of proteins. Changes in protein thiol redox state can modify the function of prote...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-02-07 | PXD042047 | Pride
Yeast Oxicat Proteostasis Thiol oxidation 
UnknownProtein S-Bacillithiolation Functions in Thiol Protection and Redox Regulation of the Glyceraldehyde-3-Phosphate Dehydrogenase Gap in Staphylococcus aureus Under Hypochlorite Stress.
Not available
S-EPMC5791933 | biostudies-literature
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