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ProteomicsEffects of the antibacterial compund Allicin from garlic on Escherichia coli
Allicin (diallyl thiosulfinate) from garlic is a highly potent natural antimicrobial substance. It inhibits growth of a variety of microorganisms, among them antibiotic resistant strains. Here, we show that upon exposure to allicin, growth of Escherichia coli is strongly inhibited. Growth inhibition...
ORGANISM(S): Escherichia coli 
2016-03-29 | PXD003158 | Pride
Cysteine Escherichia coli Allicin S-allylmercapto modification 
ProteomicsEffects of the antibacterial compund Allicin from garlic on Escherichia coli
Allicin (diallyl thiosulfinate) from garlic is a highly potent natural antimicrobial substance. It inhibits growth of a variety of microorganisms, among them antibiotic resistant strains. Here, we show that upon exposure to allicin, growth of Escherichia coli is strongly inhibited. Growth inhibition...
ORGANISM(S): Escherichia coli 
2016-05-02 | PXD003063 | Pride
Escherichia coli Allicin Thiol S-allylmercapto 
ProteomicsThe sulfur stress response and protein S-thioallylation caused by allicin and diallyl polysulfanes in Bacillus subtilis as revealed by transcriptomics and proteomics
In this study, we compared the transcriptome signatures under allicin and diallyl tetrasulfane (DAS4) exposure in the Gram-positive bacterium B. subtilis. We further used shotgun proteomics to unravel the overall S-thioallylomes provoked by allicin and DAS4. Allicin and DAS4 caused a similar thiol-s...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2019-12-09 | PXD013607 | Pride
Bacillus subtilis/ allicin/ diallyl polysulfane/ bacillithiol/ s-thioallylation 
ProteomicsThe human allicin-proteome: global protein S-thioallylation of by the garlic defence substance allicin and its biological effects
A single clove of edible garlic (Allium sativum L.) produces up to 5 mg of allicin (diallylthiosulfinate), a thiol-reactive sulfur-containing defence substance that gives injured garlic tissue its characteristic smell. Allicin induces apoptosis or necrosis in a dose-dependent manner but sublethal do...
ORGANISM(S): Homo sapiens (Human) 
2018-11-30 | PXD010201 | Pride
Interleukin il1 Il2 S-thioallylation Cytoskeleton Allicin Jurkat T-cells Protein modification Fibroblasts Cysteine Enolase Actin Zinc 
ProteomicsThe garlic compound allicin causes strong disulfide stress and protein S-sulfoallylation as revealed by proteomics and transcriptomics in Staphylococcus aureus
Allicin from garlic is an antimicrobial substance that is effective against several ESKAPE pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). However, the antimicrobial mode action of allicin has not been revealed in Gram-positive bacteria. Here, we have studied the changes in ...
ORGANISM(S): Staphylococcus aureus 
2022-02-28 | PXD010338 | Pride
Proteomics Allicin stress Transcriptomics Staphylococcus aureus S-sulfoallylation 
ProteomicsInterspecies comparison of the bacterial response to allicin reveals species-specific defense strategies
Allicin, a volatile diallylthiosulfinate from garlic (Allium sativum), exhibits broad-spectrum activity against microbial pathogens. It disrupts thiol and redox homeostasis, proteostasis, and cell membrane integrity leading to inactivation of even multidrug resistant strains. Since medicine demands ...
ORGANISM(S): Pseudomonas aeruginosa PAO1 Bacillus subtilis subsp. subtilis str. 168 
2021-03-09 | PXD012622 | Pride
Mode of action Proteomic response Bacillus subtilis Allicin Pseudomonas aeruginosa 
ProteomicsAllicin inhibits SARS-CoV-2 replication and abrogates the antiviral host response in the Calu-3 proteome
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic causes a major health burden. Garlic organosulfur compounds, such as the diallyl thiosulfinate allicin exert strong antimicrobial activity against various respiratory pathogens. Here, we investigated the antiviral activity of ...
ORGANISM(S): Homo sapiens (Human) 
2021-06-30 | PXD024375 | Pride
Sars-cov-2/ allicin/ vero e6/ calu-3/ proteome 
TranscriptomicsGlobal transcriptional profiling of Saccharomyces cerevisiae treated with allicin
We employed CapitalBio Corporation to investigate the global transcriptional profiling of Saccharomyces cerevisiae treated with allicin. S. cerevisiae strain L1190 was incubated in a rotary shaker. Subsequently, allicin was added to the culture and DMSO to the control. Then, the yeast cells were fu...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-23 | E-GEOD-11856 | biostudies-arrayexpress
TranscriptomicsThe global effect of the garlic compound Allicin on the changes in the transcriptome in Bacillus subtilis and Staphylococcus aureus USA300 analysed by RNA-seq of coding RNA
To monitor the global changes in gene expression of Staphylococcus aureus USA300 TCH1516 under exposure to the garlic compound Allicin by RNA-seq, cultivation was performed in shaking flasks in Luria Bertani (LB) medium in triplicate at 37C until cells have reached an optical density at 540nm of 2.0...
ORGANISM(S): Staphylococcus aureus subsp. aureus USA300 
2019-04-01 | E-MTAB-5667 | biostudies-arrayexpress
TranscriptomicsGlobal transcriptional profiling of Saccharomyces cerevisiae treated with allicin
We employed CapitalBio Corporation to investigate the global transcriptional profiling of Saccharomyces cerevisiae treated with allicin.
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-23 | GSE11856 | GEO
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