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ProteomicsThe sulfur stress response and protein S-thioallylation caused by allicin and diallyl polysulfanes in Bacillus subtilis as revealed by transcriptomics and proteomics
In this study, we compared the transcriptome signatures under allicin and diallyl tetrasulfane (DAS4) exposure in the Gram-positive bacterium B. subtilis. We further used shotgun proteomics to unravel the overall S-thioallylomes provoked by allicin and DAS4. Allicin and DAS4 caused a similar thiol-s...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2019-12-09 | PXD013607 | Pride
Bacillus subtilis/ allicin/ diallyl polysulfane/ bacillithiol/ s-thioallylation 
ProteomicsThe human allicin-proteome: global protein S-thioallylation of by the garlic defence substance allicin and its biological effects
A single clove of edible garlic (Allium sativum L.) produces up to 5 mg of allicin (diallylthiosulfinate), a thiol-reactive sulfur-containing defence substance that gives injured garlic tissue its characteristic smell. Allicin induces apoptosis or necrosis in a dose-dependent manner but sublethal do...
ORGANISM(S): Homo sapiens (Human) 
2018-11-30 | PXD010201 | Pride
Interleukin il1 Il2 S-thioallylation Cytoskeleton Allicin Jurkat T-cells Protein modification Fibroblasts Cysteine Enolase Actin Zinc 
UnknownThe human allicin-proteome: S-thioallylation of proteins by the garlic defence substance allicin and its biological effects.
Not available
S-EPMC6342545 | biostudies-literature
UnknownThe Disulfide Stress Response and Protein S-thioallylation Caused by Allicin and Diallyl Polysulfanes in Bacillus subtilis as Revealed by Transcriptomics and Proteomics.
Not available
S-EPMC6943732 | biostudies-literature
UnknownModification of human metallothioneins by garlic organosulfur compounds, allicin and ajoene: direct effect on zinc homeostasis with relevance to immune regulation.
Not available
S-EPMC12507958 | biostudies-literature
UnknownThe Effect of Allicin on the Proteome of SARS-CoV-2 Infected Calu-3 Cells.
Not available
S-EPMC8581659 | biostudies-literature
ProteomicsAllicin inhibits SARS-CoV-2 replication and abrogates the antiviral host response in the Calu-3 proteome
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic causes a major health burden. Garlic organosulfur compounds, such as the diallyl thiosulfinate allicin exert strong antimicrobial activity against various respiratory pathogens. Here, we investigated the antiviral activity of ...
ORGANISM(S): Homo sapiens (Human) 
2021-06-30 | PXD024375 | Pride
Sars-cov-2/ allicin/ vero e6/ calu-3/ proteome 
ProteomicsThe garlic compound allicin causes strong disulfide stress and protein S-sulfoallylation as revealed by proteomics and transcriptomics in Staphylococcus aureus
Allicin from garlic is an antimicrobial substance that is effective against several ESKAPE pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). However, the antimicrobial mode action of allicin has not been revealed in Gram-positive bacteria. Here, we have studied the changes in ...
ORGANISM(S): Staphylococcus aureus 
2022-02-28 | PXD010338 | Pride
Proteomics Allicin stress Transcriptomics Staphylococcus aureus S-sulfoallylation 
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