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TranscriptomicsMyelodysplastic/myeloproliferative neoplasms
This SuperSeries is composed of the following subset Series: GSE21948: High Density custom Agilent 44K CGH array analysis of 7q and TET2 region in myelodysplastic/myeloproliferative neoplasms GSE21990: Affymetrix SNP 6.0 array data for myelodysplastic/myeloproliferative neoplasms Refer to individual...
ORGANISM(S): Homo sapiens 
2010-06-30 | E-GEOD-21991 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for myelodysplastic syndromes (MDS) and related neoplasms
In this study, to obtain a complete registry of genetic lesions in MDS and to identify novel therapeutic targets, we performed SNP array analysis and whole exome analysis for novel mutations using high-throughput sequencing technologies. In whole exome analysis, paired CD3-positive T cells were used...
ORGANISM(S): Homo sapiens 
2011-09-11 | E-GEOD-31174 | biostudies-arrayexpress
TranscriptomicsHigh Density custom Agilent 44K CGH array analysis of 7q and TET2 region in myelodysplastic/myeloproliferative neoplasms
Abnormalities of chromosome 7q are common in myeloid malignancies. Agilent CGH arrays targeted to 7q and Affymetrix SNP 6.0 arrays were used to characterise 7q aUPD and deletions. Sample #017 in this data series showed a microdeletion encompassing EZH2. Screening of a total of 614 cases with myeloid...
ORGANISM(S): Homo sapiens 
2010-06-30 | E-GEOD-21948 | biostudies-arrayexpress
GenomicsImmune-related gene expression signatures associated with progression of myelodysplastic neoplasms
Immune-related gene expression signatures associated with progression of myelodysplastic neoplasms
PRJNA1534585 | ENA
UnknownMolecular landscape and clonal architecture of adult myelodysplastic/myeloproliferative neoplasms.
Not available
S-EPMC7645608 | biostudies-literature
ProteomicsSmall molecule inhibitors of lysyl oxidases synergize with 5-azacytidine to restore erythropoiesis in myeloid neoplasms
In this study, we assessed the effects of lysyl oxidase (LOX/LOXL) inhibition on the composition of extracellular matrix (ECM) produced by in vitro expanded bone marrow derived mesenchymal stromal cells (MSCs) of n=3 patients with myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN...
ORGANISM(S): Homo sapiens (Human) 
2023-02-17 | PXD031217 | Pride
Msc Lc-ms Human Ecm 
TranscriptomicsMDS and DNA repair defects in Crebbp+/- mice
Myelodysplastic syndrome (MDS) is considered a disease of hematopoietic stem cell (HSC) origin. To begin to unravel the molecular mechanisms underlying the deregulation of HSCs in MDS, we performed comparative gene expression profiling on Crebbp+/- and wild type HSCs. We chose to isolate HSCs from...
ORGANISM(S): Mus musculus 
2012-01-01 | E-GEOD-18061 | biostudies-arrayexpress
TranscriptomicsComprehensive array CGH of normal karyotype Myelodysplastic syndrome reveals hidden recurrent and individual genomic copy number aberrations with prognostic relevance
About 40% of patients with myelodysplastic syndromes (MDS) present with a normal karyotype and they are facing different courses of disease. To advance the biological understanding and find molecular prognostic markers we performed a high resolution oligonucleotide array study of 107 MDS patients (F...
ORGANISM(S): Homo sapiens 
2011-01-30 | E-GEOD-24602 | biostudies-arrayexpress
UnknownProspective validation of a biomarker-driven response prediction model to romiplostim in lower-risk myelodysplastic neoplasms - results of the EUROPE trial by EMSCO.
Not available
S-EPMC9522582 | biostudies-literature
UnknownAnalysis of chromatin accessibility associated with azacitidine response in higher-risk myelodysplastic neoplasms.
Not available
S-EPMC12396253 | biostudies-literature
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