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TranscriptomicsVirus-misplaced host protein activates innate immunity
Discrimination between self vs. non-self and adequate response to infection and tissue damage are fundamental functions of the immune system. The rapid and global spread of known and emerging viruses is a testament that the timely detection of viral pathogens that reproduce within host cells, presen...
ORGANISM(S): Mus musculus 
2012-10-03 | E-GEOD-36078 | biostudies-arrayexpress
MetabolomicsTGF-β uncouples glycolysis and inflammation in macrophages and controls the survival during sepsis

The mechanisms by which macrophage metabolism is regulated and the effects of metabolism on diseases remain largely unknown. We show here that TGF-β regulates the glycolysis of macrophages independently of inflammatory cytokine production, and thus affects the survival in experimental sepsis. Spe...

2023-02-17 | MTBLS6886 | MetaboLights
TranscriptomicsAnalysis of DNA methylation changes in normal human hematopoietic stem and progenitor cells
DNA methylation analysis on purified human long-term and short-term hematopoietic stem cells (LT-HSC, ST-HSC), common myeloid and megakaryocyte-erythrocyte progenitor cells (CMP, MEP) using HELP arrays. FACS-purified hematopoietic stem and progenitor cell (HSPC) subsets were analyzed for changes in ...
ORGANISM(S): Homo sapiens 
2014-02-07 | E-GEOD-52151 | biostudies-arrayexpress
GenomicsMyeloid cell coagulation factor Xa-protease activated receptor 2 signaling inhibition expands progenitor exhausted T-cells in the tumor microenvironment
Myeloid cell coagulation factor Xa-protease activated receptor 2 signaling inhibition expands progenitor exhausted T-cells in the tumor microenvironment
PRJNA885797 | ENA
UnknownMyeloid cell-synthesized coagulation factor X dampens antitumor immunity.
Not available
S-EPMC6830514 | biostudies-literature
UnknownTargeting myeloid cell coagulation signaling blocks MAP kinase/TGF-β1-driven fibrotic remodeling in ischemic heart failure.
Not available
S-EPMC9927945 | biostudies-literature
TranscriptomicsTranscription profiling of Acute Promyelocytic Leukemia samples from patients with wild type FLT3 or FLT3 mutations
In this series we described the gene expression profiles of 18 APL patients using a high density DNA-oligonucleotide microarray (Agilent) representing about 20.000 genes demonstrating the presence of a very uniform expression pattern of APL cases among which two mainly types of gene profiles were re...
ORGANISM(S): Homo sapiens 
2008-05-07 | E-GEOD-2550 | biostudies-arrayexpress
GenomicsMacrophage-expressed coagulation factor 7 promotes adverse cardiac remodeling
Macrophage-expressed coagulation factor 7 promotes adverse cardiac remodeling
PRJNA1128140 | ENA
UnknownTMEM173 Drives Lethal Coagulation in Sepsis.
Not available
S-EPMC7316085 | biostudies-literature
UnknownHematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice.
Not available
S-EPMC2918334 | biostudies-literature
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