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TranscriptomicsGene expression following myocardial infarction with and without stem cell transplantation
Background: Bone marrow-derived multipotent progenitor cell (MPC) transplantation leads to short term functional and bioenergetic improvement in a porcine model of postinfarction Left Ventricular (LV) remodeling despite a low engraftment rate. However, the long term outcome after MPC transplantation...
ORGANISM(S): Sus scrofa 
2010-04-12 | E-GEOD-14643 | biostudies-arrayexpress
TranscriptomicsMyocardial Gene Expression Profiling to Predict and Identify Cardiac Allograft Acute Cellular Rejection
Aims. Serial invasive endomyocardial biopsies (EMB) remain the gold standard for acute cellular rejection (ACR) diagnosis. However histological grading has several limitations. We aimed to explore the value of myocardial Gene Expression Profiling (GEP) for diagnosing and identifying predictive bioma...
ORGANISM(S): Homo sapiens 
2017-03-07 | E-MTAB-5136 | biostudies-arrayexpress
ProteomicsHuman HFpEF Myocardial Proteomics
Background: Heart failure with preserved ejection fraction (HFpEF) constitutes more than half of all heart failure but has few effective therapies. Recent human myocardial transcriptomics and metabolomics have revealed major differences between HFpEF, HF with reduced EF (HFrEF), and controls. How th...
ORGANISM(S): Homo sapiens (Human) 
2024-03-05 | PXD045677 | Pride
Proteomics Myocardium Obesity Molecular medicine Heart disease Human 
ProteomicsMyocardial Proteome in Human Heart Failure with Preserved Ejection Fraction
Background: Heart failure with preserved ejection fraction (HFpEF) constitutes more than half of all heart failure but has few effective therapies. Recent human myocardial transcriptomics and metabolomics have revealed major differences between HFpEF, HF with reduced EF (HFrEF), and controls. How th...
ORGANISM(S): Homo sapiens (Human) 
2025-04-11 | PXD060431 | Pride
Oxidative phosphorylation Metabolism Fatty acids Proteomics Obesity Myocardium Molecular medicine : heart failure 
TranscriptomicsComparative cardiac transcriptomics of immune checkpoint inhibitor induced myocarditis
Immune checkpoint inhibitors (ICIs) are improving cancer treatments strikingly. The raising use leads to the augmented occurrence of immune related events. Myocarditis is a rare, but severe form of these adverse events. Nine patients with proven ICI induced myocarditis were subjected to myocardial b...
ORGANISM(S): Homo sapiens 
2020-11-01 | E-MTAB-8867 | biostudies-arrayexpress
ProteomicsComputational Modelling of Myocardial Metabolism in Patients with Advanced Heart Failure
Although perturbations of myocardial metabolism and energy depletion are fundamental characteristics of heart failure (HF) pathophysiology, interindividual variability in bioenergetic phenotypes and their clinical implications remain poorly understood. Here, we used large-scale proteomics data from ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-10 | PXD053721 | Pride
Metabolism Computational modelling Heart failure Ventricular assist device Precision medicine 
TranscriptomicsTranscriptomics of cardiac biopsies reveals differences in patients with or without diagnostic parameters for heart failure with preserved ejection fraction
Heart failure affects 2–3% of adult Western population. Prevalence of heart failure with preserved left ventricular (LV) ejection fraction (HFpEF) increases. Studies suggest HFpEF patients to have altered myocardial structure and functional changes such as incomplete relaxation and increased cardiac...
ORGANISM(S): Homo sapiens 
2019-03-02 | E-MTAB-7454 | biostudies-arrayexpress
ProteomicsMyocardial proteome profiling reveals disease- and sex-specific alterations in patients with aortic valve stenosis and mitral valve regurgitation
Heart valve diseases, such as aortic valve stenosis (AS) and mitral valve regurgitation (MR), are leading causes of heart failure. However, myocardial proteome studies in AS and MR are extremely rare. We profiled the proteome of 75 human left ventricular myocardial biopsies (AS=41, MR=17, controls=1...
ORGANISM(S): Homo sapiens (Human) 
2022-12-13 | PXD023800 | Pride
Mitral regurgitation Sex differences Cytoskeleton Aortic stenosis Fibrosis Energy metabolism Proteostasis Heart Extracellular matrix 
TranscriptomicsTranscription profiling of human heart characterizing the progression of heart failure in patients with aortic valve stenosis
Myocardial left ventricular biopsies from male patients (n=6) with isolated aortic stenosis and pronounced left ventricular hypertrophy undergoing aortic valve replacement were harvested either from hearts with normal ejection fraction (EF,>50%) or with low EF (<30%). Biopsies were further obtained ...
ORGANISM(S): Homo sapiens 
2010-12-15 | E-MEXP-2296 | biostudies-arrayexpress
GenomicsRNA-seq data from submiligram porcine myocardial tissue before and after myocardial infarction
RNA-seq data from submiligram porcine myocardial tissue before and after myocardial infarction
PRJNA692626 | ENA
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