Myocardial ischemia/reperfusion injury

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Organisms

Mus musculus (69)
Rattus norvegicus (26)
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UNIPROT ID/AC

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ENSEMBL ID

ENSG00000170477 (1)
ENSG00000229353 (1)

CHEBI ID

CHEBI:72737 (2)
CHEBI:72736 (2)
CHEBI:68830 (2)
CHEBI:73054 (2)
CHEBI:16919 (2)
CHEBI:16893 (2)
CHEBI:64563 (2)
CHEBI:64561 (2)
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CHEBI:28867 (2)
CHEBI:16828 (2)
CHEBI:17925 (2)
CHEBI:16467 (2)
CHEBI:15971 (2)
CHEBI:18019 (2)
CHEBI:17368 (2)
CHEBI:16414 (2)
CHEBI:17203 (2)
CHEBI:15354 (2)
CHEBI:28728 (2)
CHEBI:17191 (2)
CHEBI:15891 (2)
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CHEBI:7916 (2)
CHEBI:37550 (2)
CHEBI:188419 (1)
CHEBI:188415 (1)
CHEBI:188406 (1)

Metabolite Name

PI 40:6 (4)
PI 38:6 (4)
PC 38:3 (4)
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PI 38:5 (4)
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Modelling Approach

Mathematical model (1)

Study type

Transcription profiling by array (26)
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Lab affiliation

Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (3)
King's College London - Cardiovascular Division (2)
Proteomics Core Facility, Sahlgrenska Academy, University of Gothenburg, Sweden (2)
Charles Perkins Centre, University of Sydney (1)
Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China. (1)
Department of Liver Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China (1)
Department of Pharmacology, Harbin Medical University, Heilongjiang 163319, China (1)
ITQB-NOVA, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. Da República, 2780-157 Oeiras, Portugal;iBET, Instituto de Biologia Experimental e Tecnológica, Apartado 12, 2780-901, Oeiras , Portugal (1)
ITQB-NOVA, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da República, 2780-157, Oeiras, Portugal; iBET- Instituto de Biologia Experimental e Tecnológica, Apartado 12 2780-901 Oeiras, Portugal (1)
King's college London, Cardiovascular Division (1)
Laboratoire de Spectrométrie de Masse BioOrganique (LSMBO), IPHC, UMR 7178, Université de Strasbourg, CNRS, 67087 Strasbourg, France; Infrastructure Nationale de Protéomique ProFI − FR2048 CNRS, 67087 Strasbourg, France (1)
Maastricht MultiModal Molecular Imaging (M4I) Institute, Division of Imaging Mass Spectrometry, Maastricht University, Maastricht, The Netherlands (1)
Massachusetts General Hospital (1)
Novo Nordisk Foundation Center for Protein Research, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark (1)
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China (1)
State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, Jiangsu, China (1)
The Second Affiliated Hospital of Jiaxing University (1)
University of Utah, Salt Lake City, Utah, United States (1)

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RNA-seq of rat myocardial tissue to investigate the cardioprotective mechanism of baicalin in myocardial ischemia-reperfusion injury

This study aimed to investigate the cardioprotective mechanism of baicalin (BAI) against myocardial ischemia-reperfusion injury (MIRI) in rats. We performed RNA-seq on left ventricular myocardial tissue from three groups: Sham (vehicle control), I/R (ischemia-reperfusion injury model), and I/R+BAI (...

ORGANISM(S): Rattus norvegicus

2026-07-31 | E-MTAB-17471 | biostudies-arrayexpress

Mongolian medicine Wulanwendusu-11 ameliorates myocardial ischemia-reperfusion injury in association with the modulation of intestinal microbiota and associated metabolic pathways

Abstract

Objective: Wulanwendusu-11 (WLWDS-11), a traditional Mongolian medicinal formula, is commonly used for the treatment of Cardiovascular diseases. However, its therapeutic material basis and in vivo metabolic profile in the context of chronic myocardial ischemia-reperfusion injury (M...

2025-11-22 | MTBLS13370 | MetaboLights

Pentose phosphate pathway-derived NADPH facilitates physiological hypertrophy and alleviates ischemia/reperfusion injury in the heart

Exercise promotes physiological cardiomyocyte growth and protects against ischemia/reperfusion (I/R) injury in the heart. The molecular mechanism by which exercise benefits cardiac metabolism and function remains largely unknown. Using a genetically encoded fluorescent indicator, we found that ex...

2026-03-22 | MTBLS14090 | MetaboLights

CaM Kinase II mediates maladaptive post-infarct remodeling but not acute myocardial ischemia/reperfusion injury

Calcium/calmodulin-dependent protein kinase II (CaMKII) was suggested to mediate ischemic myocardial injury and adverse cardiac remodeling. However, the specific functions of the CaMKII isoforms and splice variants in ischemia/reperfusion (I/R) injury have not been investigated yet. Thus, we studied...

ORGANISM(S): Mus musculus

2014-09-08 | E-GEOD-58486 | biostudies-arrayexpress

The dynamic changes and mechanism of no reflow injury after myocardial ischemia-reperfusion

This study aims to investigate the dynamic changes and correlation of no-reflow (NR) injury following myocardial ischemia and reperfusion, and to explore the underlying mechanism of NR injury through transcriptomic and metabolomic analysis. Methods: Healthy male SD rats were divided into two batches...

2026-08-25 | MTBLS15452 | MetaboLights

Pentose phosphate pathway-derived NADPH facilitates physiological hypertrophy and alleviates ischemia/reperfusion injury in the heart

2026-04-13 | MTBLS14264 | MetaboLights

RNA microarray of rat kidney treated with or without silicon nano-particles against ischemia reperfusion injury

RNA microarray was performed to evaluate the efficacy of silicon nano-particles on renal transcriptomes of rats against ischemia reperfusion injury. We compared the transcriptomes of ischemia reperfusion injury model rats with or without oral administration of silicon nano-particles. We also tried t...

ORGANISM(S): Rattus norvegicus

2020-02-04 | E-MTAB-8687 | biostudies-arrayexpress

Integrated transcriptomic and metabolomic analysis reveals the regulatory role of Itaconic acid in inflammatory infiltration during myocardial Ischemia-Reperfusion injury

Following establishment of a myocardial ischemia-reperfusion model, tissue samples from the infarct border zone were harvested for transcriptomics and wide-target metabolomic sequencing. Bioinformatics methods were used to analyse the transcriptomics and metabolomics results separately and to per...

2025-10-14 | MTBLS12934 | MetaboLights

Metabolomic data related to the alleviation of cardiac ischemia/reperfusion injury by NADPH derived from pentose phosphate pathway

Exercise promotes physiological cardiomyocyte growth and protects against ischemia/reperfusion (I/R) injury in the heart. The molecular mechanism by which exercise benefits cardiac metabolism and function remains largely unknown. Exercise (swimming or treadmill)-induced physiological hypertrophy ...

2026-05-14 | MTBLS14272 | MetaboLights

Impact of myocardial reperfusion on human plasma lipidome

The primary aim of the study is to investigate the temporal changes in plasma lipidome before and after reperfusion in patients with ST-segment elevation myocardial infarction (STEMI) and their association with myocardial injury. We found that 56% of the identified lipid species were significantly a...

2022-02-07 | MTBLS3839 | MetaboLights

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