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UnknownMulti-omics Insight into Cardiac Myofibril Remodeling in Post-Prandial Burmese Pythons.
Not available
S-EPMC12889742 | biostudies-literature
UnknownSite-specific acetyl-mimetic modification of cardiac troponin I modulates myofilament relaxation and calcium sensitivity.
Not available
S-EPMC7363438 | biostudies-literature
UnknownInstrumentation to study myofibril mechanics from static to artificial simulations of cardiac cycle.
Not available
S-EPMC4796715 | biostudies-literature
ProteomicsHDAC inhibition improves cardiopulmonary and mitochondrial function in a feline model with features of Heart Failure with Preserved Ejection Fraction
Heart Failure with preserved Ejection Fraction (HFpEF) is a major global health problem but there are no effective therapies. The aim of this study was to assess the effects of histone deacetylase (HDAC) inhibition on cardiopulmonary structure, function, and metabolism in a large mammalian (feline) ...
ORGANISM(S): Felis catus (Cat) (Felis silvestris catus) 
2021-09-08 | PXD013663 | Pride
Myofibril relaxation Hypertrophy Cat Hdac Heart failure Acetylation proteomics Pulmonary hypertension Lung compliance 
UnknownPKA phosphorylation of cardiac troponin I modulates activation and relaxation kinetics of ventricular myofibrils.
Not available
S-EPMC4156663 | biostudies-literature
TranscriptomicsHDAC Inhibition Reverses Preexisting Diastolic Dysfunction and Blocks Covert Extracellular Matrix Remodeling
Background: Diastolic dysfunction (DD) is associated with the development of heart failure and contributes to the pathogenesis of other cardiac maladies, including atrial fibrillation. Inhibition of histone deacetylases (HDACs) has been shown to prevent DD by enhancing myofibril relaxation. We addre...
ORGANISM(S): Mus musculus 
2026-05-26 | GSE333327 | GEO
TranscriptomicsRNA-sequencing analysis of ZsYellow-negative cells and ZsYellow-positive cardiopharyngeal progenitors and cardiomyocytes purified from the same 14-16 somites stage Tg(nkx2.5:ZsYellow) zebrafish embryos
The identification of novel cardiomyocyte-intrinsic factors that support ventricular function will expand the number of candidate genes and therapeutic options for heart failure, a leading cause of death worldwide. Here, we demonstrate that a conserved RNA-binding protein RBPMS2 is required for vent...
ORGANISM(S): Danio rerio 
2022-09-04 | GSE167416 | GEO
TranscriptomicsRNA-sequencing of rbpms2a; rbpms2b double-mutant and control-sibling zebrafish embryos at 33 hours post fertilization.
The identification of novel cardiomyocyte-intrinsic factors that support ventricular function will expand the number of candidate genes and therapeutic options for heart failure, a leading cause of death worldwide. Here, we demonstrate that a conserved RNA-binding protein RBPMS2 is required for vent...
ORGANISM(S): Danio rerio 
2022-09-04 | GSE167414 | GEO
UnknownHistone deacetylase activity governs diastolic dysfunction through a nongenomic mechanism.
Not available
S-EPMC5908215 | biostudies-literature
UnknownImpaired Relaxation in Induced Pluripotent Stem Cell-Derived Cardiomyocytes with Pathogenic TNNI3 Mutation of Pediatric Restrictive Cardiomyopathy.
Not available
S-EPMC11010001 | biostudies-literature
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