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ProteomicsCardiac myofilament isoforms - Identification of cardiac myofilament protein isoforms using multiple mass spectrometry based approaches
Purpose: The identification of protein isoforms in complex biological samples is challenging. We, therefore, used a mass spectrometry (MS) approach to unambiguously identify cardiac myofilament protein isoforms based on the observation of a tryptic peptide consisting of a sequence unique to a partic...
ORGANISM(S): Rattus norvegicus (Rat) 
2014-08-28 | PXD000874 | Pride
Multiple search engines Bioinformatics Cardiomyocyte Sarcomere Protein isoforms Rat cardiac tissue Myofilament proteome Protein sub-isoforms Lc-ms/ms 
ProteomicsCardiomyocyte Contractile Impairment in Heart Failure Results from Reduced BAG3-mediated Sarcomeric Protein Turnover
The association between reduced myofilament force-generating capacity (Fmax) and heart failure (HF) is clear, however the underlying molecular mechanisms are poorly understood. Here, we show impaired Fmax arises from reduced BAG3-mediated sarcomere turnover. Myofilament BAG3 expression decreases in ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2020-11-06 | MSV000086422 | MassIVE
ProteomicsMechanical forces regulate cardiomyocyte myofilament maturation via the VCL-SSH1-CFL axis
Mechanical forces regulate cell behavior and tissue morphogenesis. In particular, cardiac tissues require mechanical stimuli generated by the heartbeat for differentiation and maturation, but the molecular mechanisms underlying these processes remain unclear. Here, we first show that mechanical fo...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-09-06 | PXD014624 | Pride
Heart Rattus norvegicus Cardiac contractility 
UnknownS-Nitrosylation of Sarcomeric Proteins Depresses Myofilament Ca2+)Sensitivity in Intact Cardiomyocytes.
Not available
S-EPMC4649751 | biostudies-literature
UnknownFirst profiling of lysine crotonylation of myofilament proteins and ribosomal proteins in zebrafish embryos.
Not available
S-EPMC5827021 | biostudies-literature
UnknownPost-translational modifications of myofilament proteins involved in length-dependent prolongation of relaxation in rabbit right ventricular myocardium.
Not available
S-EPMC3640662 | biostudies-literature
UnknownO-linked GlcNAc modification of cardiac myofilament proteins: a novel regulator of myocardial contractile function.
Not available
S-EPMC2615199 | biostudies-literature
UnknownIdentification of cardiac myofilament protein isoforms using multiple mass spectrometry based approaches.
Not available
S-EPMC4222538 | biostudies-literature
UnknownProtein Kinase D Plays a Crucial Role in Maintaining Cardiac Homeostasis by Regulating Post-Translational Modifications of Myofilament Proteins.
Not available
S-EPMC10932171 | biostudies-literature
UnknownProteomics analysis of the cardiac myofilament subproteome reveals dynamic alterations in phosphatase subunit distribution.
Not available
S-EPMC2849712 | biostudies-literature
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