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GenomicsAssessment of myogenic maturation for human iPSC-derived iPAX7 myogenic progenitors in vitro and in vivo
Assessment of myogenic maturation for human iPSC-derived iPAX7 myogenic progenitors in vitro and in vivo
PRJNA1023472 | ENA
Proteomics3D bioprinting directly affects proteomic signature and myogenic maturation in muscle pericytes-derived human myo-substitute
Skeletal muscle tissue engineering (SMTE) has recently emerged to address major clinical challenges such as volumetric muscle loss. Here, we report a rotary wet-spinning (RoWS) biofabrication technique for producing human myo-substitutes with biomimetic architectures and functions. Here, we demonstr...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD043605 | Pride
Myogenic maturation Myosubstitute Bioprinting Perycites 
TranscriptomicsmiR-487b, miR-3963 and miR-6412 delayed myogenic differentiation in C2C12 mouse myoblast-derived cells.
We newly identified skeletal muscle differentiation-associated miRNAs by comparing miRNA expression profile between C2C12 cell and Wnt4-overexpressing C2C12 cell. miR-487b, miR-3963 and miR-6412 are significantly down-regulated in differentiating C2C12 cells, and transfection of their mimics result...
ORGANISM(S): Mus musculus 
2015-11-24 | E-GEOD-63454 | biostudies-arrayexpress
UnknownYthdf2 facilitates precursor miR-378/miR-378-5p maturation to support myogenic differentiation.
Not available
S-EPMC11541164 | biostudies-literature
TranscriptomicsThe RNA binding protein Arrest (Aret) regulates myofibril maturation in Drosophila flight muscle
In Drosophila, fibrillar flight muscles (IFMs) enable flight, while tubular muscles mediate other body movements. Here, we use RNA-sequencing and isoform-specific reporters to show that spalt major (salm) determines fibrillar muscle physiology by regulating transcription and alternative splicing of ...
ORGANISM(S): Drosophila melanogaster 
2014-12-23 | E-GEOD-63707 | biostudies-arrayexpress
UnknownROCK2 and its alternatively spliced isoform ROCK2m positively control the maturation of the myogenic program.
Not available
S-EPMC1952159 | biostudies-literature
UnknownHuman pluripotent stem cell-derived myogenic progenitors undergo maturation to quiescent satellite cells upon engraftment.
Not available
S-EPMC9000524 | biostudies-literature
TranscriptomicsA Pitx2-miRNA pathway modulates cell proliferation in myoblasts and skeletal-muscle satellite cells and promotes their commitment to a myogenic cell fate.
The acquisition of a proliferating cell status from a quiescent state as well as the shift between proliferation and differentiation are key developmental steps in skeletal-muscle stem cells (satellite cells) to provide proper muscle regeneration. However, how satellite-cell proliferation is regulat...
ORGANISM(S): Mus musculus 
2015-06-10 | E-GEOD-53943 | biostudies-arrayexpress
TranscriptomicsAssessment of myogenic maturation for human iPSC-derived iPAX7 myogenic progenitors in vitro and in vivo
Here, we transplanted human iPAX7 myogenic progenitors into skeletal muscles of non-dystrophic and dystrophic mice and compared the transcriptional landscape of human donor-derived myofibers with respective in vitro-differentiated iPAX7 myotubes. Pairing bulk RNA sequencing with computational deconv...
ORGANISM(S): Homo sapiens Mus musculus 
2024-04-02 | GSE244521 | GEO
TranscriptomicsTranscription profiling of C2C12 myoblasts induced to differentiate in vitro over a 12 day time series to identify novel genes involved in myogenic differentiation.
In this study, Affymetrix MG_U74Av2 and MG_U74Cv2 GeneChips were used to analyze gene expression over a 12 day time course in C2C12 myoblasts induced to differentiate in vitro. Triplicate cultures were studied during cell proliferation (days -2 and -1), at cell cycle withdrawal (day 0) and during m...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-990 | biostudies-arrayexpress
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