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ProteomicsFAK modulates glioblastoma stem cell energetics via actomyosin contractility: regulation of glycolysis and mitochondrial function
Glycolysis and the TCA cycle are commonly reprogrammed to fulfil the bioenergetic and biosynthetic demands of cancer cells. Although the extracellular matrix is known to influence glycolysis and the TCA cycle, it is not well understood how specific adhesion proteins and their downstream effectors c...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-15 | PXD058998 | Pride
Fak Metabolims 
ProteomicsDysregulated Skeletal Muscle Myosin Super-relaxation in Type II, but Not Type I, Diabetes Mellitus
Skeletal muscle plays a critical role in the onset and development of type II diabetes. However, very few studies have investigated the potential pathogenic role of its most abundant protein, myosin. Hence, here, we aim to define this by focusing on myosin energy-saving state known as super-relaxed ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-29 | PXD053022 | Pride
Proteomics Single muscle fiber Skeletal muscle Diabetes 
UnknownMatching Mechanics and Energetics of Muscle Contraction Suggests Unconventional Chemomechanical Coupling during the Actin-Myosin Interaction.
Not available
S-EPMC10418673 | biostudies-literature
UnknownMyosin cleft closure determines the energetics of the actomyosin interaction.
Not available
S-EPMC3005428 | biostudies-literature
UnknownMyosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy.
Not available
S-EPMC7077965 | biostudies-literature
UnknownHuman cardiac β-myosin powerstroke energetics: Thin filament, Pi displacement, and mutation effects.
Not available
S-EPMC11427785 | biostudies-literature
ProteomicsIntegrated Single-Fiber Multi-Omics in ICU-acquired weakness
Skeletal muscle dysfunction is a pervasive complication of critical illness that worsens survival and recovery, yet remains poorly explained by current clinical or molecular markers. To directly connect disease-associated molecular states to the contractile machinery, this study combined sequential ...
ORGANISM(S): Homo sapiens (Human) 
2026-10-20 | PXD073993 | Pride
Critical illness Myosin energetics Multi-omics Muscle weakness Skeletal muscle heterogeneity Single-fiber analysis 
UnknownElectrostatic origin of the unidirectionality of walking myosin V motors.
Not available
S-EPMC3808596 | biostudies-literature
UnknownAnisotropic Elasticity of the Myosin Motor in Muscle.
Not available
S-EPMC8909946 | biostudies-literature
UnknownHeart failure drug changes the mechanoenzymology of the cardiac myosin powerstroke.
Not available
S-EPMC5347578 | biostudies-literature
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