Myosin light chain kinase

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Transcriptomics (2361)
Unknown (677)
Genomics (51)
Proteomics (43)
Metabolomics (6)
Models (1)
Methylation profiling (1)
Multiomics (1)

Organisms

Homo sapiens (1405)
Mus musculus (607)
Rattus norvegicus (75)
Arabidopsis thaliana (56)
Danio rerio (37)
Schizosaccharomyces pombe (34)
Drosophila melanogaster (31)
Bos taurus (15)
Sus scrofa (13)
Gallus gallus (11)
Saccharomyces cerevisiae (11)
Caenorhabditis elegans (9)
Macaca mulatta (6)
synthetic construct (6)
Campylobacter jejuni (5)
Streptococcus pneumoniae (5)
Apostichopus japonicus (4)
Apis mellifera (4)
Zea mays (4)
Larix kaempferi (3)
Aplysia californica (3)
Bombyx mori (3)
Notophthalmus viridescens (2)
Neisseria gonorrhoeae (2)
Salmonella enterica (2)
Papio hamadryas (2)
Oryza sativa Indica Group (2)
Felis catus (2)
Oryza sativa (2)
Ovis aries (2)

Organisms

Homo sapiens (8)
Mus musculus (6)
Rattus norvegicus (1)

Repository

biostudies-arrayexpress (2383)
pride (17)
ENA (17)
geo (15)
jPOST (9)
MassIVE (7)
iProX (6)
MetaboLights (6)
EGA (5)
PanoramaPublic (2)
BioModels (1)

Tissue

Heart (3)
Cell culture (3)
Epithelial cell (2)
HEK-293FT cell (1)
Myometrial cell (1)
Myometrium (1)
Primary cell (1)
Muscle (1)
Fibroblast (1)
Cell suspension culture (1)
T cell (1)
Embryo (1)
Whole body (1)

Disease

Normal (13)
Acute myeloid leukemia (4)
Chronic lymphocytic leukemia (3)
Neuroblastoma (3)
Colorectal cancer (2)
Breast cancer (2)
HIV encephalitis (1)
High grade glioblastoma (1)
Breast Normal (1)
Unspecified peripheral T-cell lymphoma (1)
Tumor (1)
Embryonic lethal at day 8.5 to 9.5 (1)
Invasive Ductal Carcinoma (1)
Colorectal cancer recurrence-free (1)
Uncomplicated gonorrhoea (1)
Chronic infection with geohelminth ascaris lumbricoides (1)
Marsh 3 (1)
Untreated prostate cancer (1)
Dukes D primary colon cancer (1)
Lung large cell carcinoma (1)
Lupus (1)
Bronchioloalveolar carcinoma of lung (1)
Colon cancer metastasis (1)
Malignant melanoma (1)
Early-onset idiopathic chronic pancreatitis (1)
None- acute control (1)
Disease controled patient (1)
Squamous cell carcinoma (1)
Leukemia (1)
Colon cancer (1)

Technology Type

Mass Spectrometry (17)
Shotgun proteomics (6)
Mass spectrometry (3)
Mass spectrometry assay (3)
Gel-based experiment (3)
Affinity purification coupled with mass spectrometry proteomics (3)
Bottom-up proteomics (2)
Illumina HiSeq 2000 (1)
Top-down proteomics (1)
Data-dependent acquisition (1)
Data-independent acquisition (1)

Instrument Platform

Illumina NovaSeq 6000 (25)
Illumina HiSeq 2500 (23)
NextSeq 500 (17)
Axon GenePix 4000A scanning hardware (15)
Illumina HiSeq 2000 (14)
Axon GenePix 4000B scanning hardware (13)
Scanning hardware (10)
Illumina HiSeq 4000 (10)
ScanArray 4000XL [PerkinElmer] (7)
GenePix 4000B [Axon Instruments] (5)
Vortex (5)
ScanArray Express HT [PerkinElmer] (4)
HiSeq X Ten (4)
GenePix Professional 4200A [Axon Instruments] (3)
G2565AA DNA microarray scanner [Agilent] (3)
G2565BA DNA microarray scanner [Agilent] (3)
Beadarray reader (2)
Illumina HiScanSQ (2)
GenePix 4000A [Axon Instruments] (2)
Illumina Genome Analyzer IIx (2)
Axon- GenePix4000B (2)
ScanArray Express HT (2)
Illumina MiSeq (2)
Illumina HiSeq 1500 (2)
Illumina HiSeq 2000 platform (1)
MiRDeep2 and miRBase. v22 database (1)
NaN (1)
10x Genomics Chromium controller; Agilent 2100 Bioanalyzer and Qubit fluorometer (Thermo Fisher) for QC (1)
10x Genomics Chromium controller (GEM generation on Chromium Next GEM Chip G) (1)
BD FACSAria cell sorter (viable-cell sorting); Countess III cell counter (Thermo Fisher; viability check) (1)

Publication Date

2014 (347)
2013 (323)
2012 (321)
2015 (315)
2011 (230)
2010 (212)
2016 (199)
2009 (70)
2008 (61)
2007 (51)
2005 (50)
2022 (34)
2006 (29)
2018 (26)
2020 (24)
2024 (23)
2021 (22)
2017 (21)
2019 (19)
2004 (19)
2025 (17)
2026 (16)
2023 (15)
2003 (1)

UNIPROT ID/AC

Q03113 (1)
P62873 (1)
P63211 (1)
Q96A00 (1)
Q9NRY4 (1)
Q92888 (1)
Q14643 (1)
O14974 (1)
O94810 (1)
P17252 (1)
P25116 (1)
P00734 (1)
P29992 (1)
Q9NQ66 (1)
P05976 (1)
Q9H1R3 (1)
P62158 (1)
Q13464 (1)
P61586 (1)

CHEBI ID

CHEBI:18348 (1)
CHEBI:18035 (1)
CHEBI:17268 (1)
CHEBI:16595 (1)
CHEBI:29108 (1)
CHEBI:15996 (1)
CHEBI:17552 (1)
CHEBI:144332 (1)
CHEBI:77154 (1)
CHEBI:183886 (1)
CHEBI:30657 (1)
CHEBI:73961 (1)
CHEBI:73812 (1)
CHEBI:73259 (1)
CHEBI:50281 (1)
CHEBI:74797 (1)
CHEBI:28134 (1)
CHEBI:16118 (1)
CHEBI:176504 (1)
CHEBI:28358 (1)
CHEBI:33283 (1)
CHEBI:16497 (1)
CHEBI:72961 (1)
CHEBI:77996 (1)
CHEBI:36141 (1)
CHEBI:79096 (1)
CHEBI:57593 (1)
CHEBI:15552 (1)
CHEBI:28189 (1)
CHEBI:44401 (1)

Metabolite Name

L-Palmitoylcarnitine (2)
5-Methylcytidine (2)
N-Palmitoylsphingosine (2)
1-Aminocyclopropanecarboxylic acid (2)
Betaine aldehyde (2)
Cholic acid (2)
PC(16:0/16:0) (2)
Thiamine (2)
5-Methylcytosine (2)
Histamine (2)
Choline (2)
Uracil (2)
Xanthosine (2)
L-Carnitine (2)
Trimethylamine N-oxide (2)
L-Tyrosine (2)
Hypoxanthine (2)
Phosphorylcholine (2)
N-Acetyl-L-alanine (2)
L-Glutamine (2)
Dihydrouracil (2)
Riboflavin (2)
L-Phenylalanine (2)
D-Proline (2)
Creatine (2)
Cytosine (2)
Glycerophosphocholine (2)
L-Methionine (2)
N4-Acetylcytidine (2)
Trigonelline (2)

First Public Date

2024 (5)
2022 (3)
2014 (3)
2016 (2)
2025 (1)
2020 (1)
2018 (1)
2015 (1)

Modelling Approach

Ordinary differential equation model (1)

Lab affiliation

Centre for Heamato-Oncology / Barts Cancer Institute (1)
Epithelial Systems Biology Laboratory Systems Biology Center Division of Intramural Research NHLBI, NIH USA (1)
VIB Department of Medical Protein Research, UGent Proteome Analysis and Bioinformatics Unit B9000 Gent, Belgium (1)
ZMBH, University Heidelberg Im Neuenheimer Feld 282 69120 Heidelbe4rg Germany (1)
Department of Pathogen Biology, School of Clinical and Basic Medicine, Shandong First Medical University &Shandong Academy of Medical Sciences (1)
u o edinburgh (1)
Division of Pediatric Cardiology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, 30322, USA (1)
Institute of Parasitology, Polish Academy of Sciences (1)
Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA (1)
Institute of Cancer Research, Division of Cancer Biology, 237 Fulham Road, London SW3 6JB, UK. (1)
Molecular Allergy Research Laboratory, Centre for Sustainable Tropical Fisheries and Aquaculture (CSTFA), College of Science and Engineering, James Cook University, Douglas, QLD 4811, Australia Tropical Futures Institute, James Cook University, 149 Sims Drive, Singapore 387380, Singapore (1)
ZMBH, University Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany (1)
The First Affiliated Hospital, Sun Yat-sen University (1)
Lee Kong Chian School of Medicine, Nanyang Technological University Singapore (1)
Associate Professor, University of Nevada, Reno department of Pharmacology (1)
University of Copenhagen, Department of Biomedical Sciences, Jepps Lab, Copenhagen, Denmark (1)
Centre of Molecular Biology University Heidelberg Im Neuenheimer Feld 282 D-69120 Heidelberg Germany (1)

IsPrivate

False (1)

Modification

32.056407 (1)
45.029395 (1)
-17.026549 (1)
42.010565 (1)
15.994915 (1)
+3amu) (1)

Study type

Transcription profiling by array (1687)
RNA-seq of non coding RNA (190)
RNA-seq of coding RNA (145)
MicroRNA profiling by array (90)
Transcription profiling by RT-PCR (55)
Other (50)
Comparative genomic hybridization by array (22)
MicroRNA profiling by high throughput sequencing (20)
ChIP-seq (18)
ChIP-chip by array (17)
Methylation profiling by array (8)
Unknown experiment type (7)
Human - High-throughput sequencing (6)
RNA-seq of coding RNA from single cells (6)
Methylation profiling by high throughput sequencing (6)
RNA-seq of total RNA (6)
Genotyping by array (5)
RNAi profiling by array (4)
Animal - One-color microarray (3)
MicroRNA profiling by high-throughput sequencing (3)
Cell line - One-color microarray (3)
Transcription profiling by tiling array (3)
4C (3)
RIP-seq (3)
ChIP-chip by tiling array (2)
Animal - High-throughput sequencing (2)
Cell line - High-throughput sequencing (2)
DNA-seq (2)
Proteomic profiling by array (2)
Transcription profiling by SAGE (1)

Release Date

2014 (385)
2015 (356)
2013 (350)
2012 (344)
2011 (273)
2010 (232)
2016 (225)
2009 (84)
2008 (81)
2022 (79)
2023 (67)
2018 (67)
2020 (66)
2021 (63)
2007 (62)
2005 (54)
2017 (49)
2024 (48)
2019 (43)
2006 (39)
2025 (35)
2004 (21)
2026 (18)
2003 (5)
2002 (5)
2001 (2)
1998 (2)
1991 (2)
2000 (1)
1992 (1)

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CRISPR-Cas9/phosphoproteomics identifies Myosin Light Chain Kinase dependent signaling in kidney epithelial cells

Prior studies have implicated myosin light chain kinase (MLCK) in the regulation of aqua-porin-2 (AQP2) in the renal collecting duct. To discover signaling targets of MLCK, we deleted the Mylk- gene to obtain MLCK-null mpkCCD cells and carried out comprehensive phosphopro-teomics using the SILAC met...

ORGANISM(S): Mus musculus (Mouse)

2020-03-04 | PXD014985 | Pride

Analysis of myosin light chain migration pattern in 2D gels of human left ventricular proteins

The myosin light chain protein family consists of two classes, the regulatory myosin light chains (RLC) and the essential myosin light chains (ELC). Functionally, the MLC proteins are directly involved in sarcomeric activity and force transmission contributing to cardiac contractility. Besides regul...

ORGANISM(S): Homo sapiens (Human)

2022-07-24 | PXD033908 | Pride

Cardiomyocytes Essential myosin light chains (elc) Phosphorylation Regulatory myosin light chains (rlc)

Smooth muscle myosin light chain kinase efficiently phosphorylates serine 15 of cardiac myosin regulatory light chain.

Not available

S-EPMC3242870 | biostudies-literature

MYBPH, a novel transcriptional target of NKX2-1/TTF-1, inhibits ROCK1 and actomyosin assembly, and reduces cell motility and tumor metastasis

Cell migration driven by actomyosin filament assembly is a critical step in tumour invasion and metastasis. Herein, we report identification of myosin binding protein H (MYBPH) as a transcriptional target of NKX2-1 (also known as TTF-1 and TITF1), a lineage-survival oncogene in lung adenocarcinoma. ...

ORGANISM(S): Homo sapiens

2011-12-22 | E-GEOD-26721 | biostudies-arrayexpress

Myosin light chain kinase (MLCK) regulates cell migration in a myosin regulatory light chain phosphorylation-independent mechanism.

Not available

S-EPMC4192498 | biostudies-literature

Domain characterization of rabbit skeletal muscle myosin light chain kinase.

Not available

S-EPMC4325999 | biostudies-literature

Molecular characterization of a mammalian smooth muscle myosin light chain kinase.

Not available

S-EPMC2836767 | biostudies-literature

Analysis of myosin light chain migration pattern in 2D gels of human left ventricular proteins - proximity labeling

NIMA-related kinase 9 (NEK9) was identified to interact with the essential myosin light chain (ELC). To validate these findings ascorbate peroxidase (APEX) catalyzed proximity labeling (Hung et al. Nat Protoc. 2016) was performed. To do so, human ELC fused to APEX was overexpressed in HEK293 cells. ...

ORGANISM(S): Homo sapiens (Human)

2022-07-24 | PXD034115 | Pride

Bioid Nek9 Elc

RNP immunoprecipitation of fission yeast using Rng3p myosin-specific chaperones to investigate if the association of Rng3p with RNAs occurs on ribosomes

Ribonucleoprotein immunoprecipitation microarray (RIp-chip) study using the Rng3p myosin-specific chaperones from the fission Schizosaccaromyces pombe. Rng3p associates with RNAs encoding myosins. To investigate if the association of Rng3p with these RNAs occurs on ribosomes, Rng3-purified fractio...

ORGANISM(S): Schizosaccharomyces pombe

2008-12-23 | E-TABM-564 | biostudies-arrayexpress

Biochemistry of smooth muscle myosin light chain kinase.

Not available

S-EPMC3382066 | biostudies-literature

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