Obesity, a globally prevalent chronic metabolic disorder, has been increasingly confirmed to involve gut microbiota as a pivotal regulator in its pathogenesis. Chlorogenic acid (CGA) has been reported to exert beneficial effects on lipid metabolism regulation and obesity amelioration. However, t...
Mitochondrial fatty acid β-oxidation (FAO) is essential for energy production and cellular homeostasis, yet its specific role in sperm function has remained unclear. Through whole-exome sequencing of 673800 patients with asthenozoospermia, we identified biallelic TEX44 variants in six individuals...