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ProteomicsMytho, An Uncharacterized Gene that Controls Longevity and WIPI2-dependent Autophagy
The identification of genes that confer either extension of life span or accelerate age-related decline was a step forward in our understanding the mechanisms of senescence and revealed that aging process is partially controlled by genetics and transcriptional programs. Here we identified that the u...
ORGANISM(S): Homo sapiens (Human) 
2024-07-02 | PXD022180 | Pride
Wipi2 Autophagy Longevity Mytho 
GenomicsMYTHO: a novel regulator of skeletal muscle autophagy and integrity
MYTHO: a novel regulator of skeletal muscle autophagy and integrity
PRJNA923700 | ENA
UnknownMYTHO is a novel regulator of skeletal muscle autophagy and integrity.
Not available
S-EPMC9981687 | biostudies-literature
TranscriptomicsMYTHO: a novel regulator of skeletal muscle autophagy and integrity
Autophagy is a critical process in the regulation of muscle mass, function and integrity. The molecular mechanisms regulating autophagy are complex and still partly understood. Here, we identify and characterize a novel FoxO-dependent gene, d230025d16rik which we named Mytho (Macroautophagy and YouT...
ORGANISM(S): Mus musculus 
2023-01-20 | GSE222885 | GEO
UnknownC16ORF70/MYTHO promotes healthy aging in C.elegans and prevents cellular senescence in mammals.
Not available
S-EPMC11291266 | biostudies-literature
GenomicsMYTHO: a novel regulator of skeletal muscle autophagy and integrity [3 weeks]
MYTHO: a novel regulator of skeletal muscle autophagy and integrity [3 weeks]
PRJNA923704 | ENA
GenomicsMYTHO: a novel regulator of skeletal muscle autophagy and integrity [3 months]
MYTHO: a novel regulator of skeletal muscle autophagy and integrity [3 months]
PRJNA905094 | ENA
GenomicsMytho/Phaf1 is required to prevent DNA damage and tissue degeneration in Danio rerio
Mytho/Phaf1 is required to prevent DNA damage and tissue degeneration in Danio rerio
PRJNA1411997 | ENA
TranscriptomicsMytho/Phaf1 is required to prevent DNA damage and tissue degeneration in Danio rerio
Mytho (Macroautophagy and YouTH Optimizer) is a novel FoxO-dependent gene that has been recently identified to control health- and life-span in C. elegans via autophagy regulation. However, the role of this gene in tissue development and function in vertebrates has not yet been established. To addre...
ORGANISM(S): Danio rerio 
2026-04-17 | GSE317380 | GEO
TranscriptomicsMYTHO: a novel regulator of skeletal muscle autophagy and integrity [3 weeks]
Short-term MYTHO knockdown (KD) mRNA expression data for the mouse muscle (n=4 per group) were obtained using Affymetrix Mouse Clariom S Assay (Affymetrix, Santa Carla, CA) according to the manufacturer’s recommendations.
ORGANISM(S): Mus musculus 
2023-01-19 | GSE222884 | GEO
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